Oncotarget

Research Papers:

Prevalence characteristics of high-risk human papillomaviruses in women living in Shanghai with cervical precancerous lesions and cancer

Ying Gu _, Chenyun Ma, Jue Zou, Yi Zhu, Rong Yang, Yan Xu and Yu Zhang

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Oncotarget. 2016; 7:24656-24663. https://doi.org/10.18632/oncotarget.8262

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Abstract

Ying Gu1, Chenyun Ma2, Jue Zou3, Yi Zhu1, Rong Yang1, Yan Xu1, Yu Zhang1

1Department of Gynaecology and Obstetrics, The Seventh People’s Hospital of Shanghai University of TCM, The New Pudong District, Shanghai 200137, China

2Clinical Laboratory, The Seventh People’s Hospital of Shanghai University of TCM, The New Pudong District, Shanghai 200137, China

3Department of Pathology, The Seventh People’s Hospital of Shanghai University of TCM, The New Pudong District, Shanghai 200137, China

Correspondence to:

Yu Zhang, e-mail: zyzhangyu2015@sina.com

Keywords: high-risk human papillomaviruses, cervicitis, cervical intraepithelial neoplasia grade 1 to 3, invasive squamous cell carcinoma

Received: January 11, 2016    Accepted: March 04, 2016    Published: March 22, 2016

ABSTRACT

A complete understanding of the natural history of infection with high-risk human papillomaviruses (HPVs) in cervical cancer requires data from regional and ethnic studies. The prevalence of high-risk HPVs was evaluated retrospectively in 2040 patients with cervicitis, 239 with cervical intraepithelial neoplasia grade 1 (CIN1), 242 with CIN2/3, and 42 patients with invasive squamous cell carcinoma (SCC) based on data from patients who visited our hospital between May 2013 and May 2015. The rates of high-risk HPV infection in patients with cervicitis, CIN1, CIN2/3, and invasive SCC were 40.8%, 74.9%, 70.2%, and 83.3%, respectively. The three most dominant HPV genotypes were HPV16, 58, and 52. HPV16 and HPV58 positivity in cervicitis, CIN1, CIN2/3, and SCC patients were 20.9% and 16.4%, 19.0% and 20.1%, 44.1% and 23.5%, and 60.0% and 31.4%, respectively. Compared to cervicitis, the odds ratios (ORs) for CIN2/3 in HPV16- and HPV58-positive patients were 2.99 (95% confidence interval [CI]: 1.32–4.33) and 1.56 (1.11–3.21), respectively; for SCC, the corresponding values were 5.68 (2.31–7.893) and 2.33 (1.41–3.87). Further identifying of carcinogenic HPVs and a fully aware of regional differences in HPV genotype distribution are tasks of top priority for cervical cancer control and prevention.


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