From kinetics and cellular cooperations to cancer immunotherapies

Alain Trautmann _

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Oncotarget. 2016; 7:44779-44789. https://doi.org/10.18632/oncotarget.8242

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Alain Trautmann1,2,3,4

1 INSERM, U1016, Institut Cochin, Paris, France

2 CNRS, UMR8104, Paris, France

3 Université Paris Descartes, Sorbonne Paris Cité, Paris, France

4 Equipe Labellisée “Ligue contre le Cancer”, Paris, France

Correspondence to:

Alain Trautmann, email:

Keywords: immunotherapy, kinetics, cellular cooperation

Received: February 02, 2016 Accepted: March 04, 2016 Published: March 21, 2016


In this review will be underlined two simple ideas of potential interest for the design of cancer immunotherapies. One concerns the importance of kinetics, with the key notion that a single cause may trigger two opposite effects with different kinetics. The importance of this phenomenon will be underlined in neurobiology, transcription networks and the immune system. The second idea is that efficient immune responses have been selected against pathogens, throughout evolution. They are never due to a single cell type, but always require multiple, complex cellular cooperations. One cannot recognize this fact and persist in the presently dominant T-cell centered view of cancer immunotherapies. Suggestions will be made to incorporate these simple ideas for improving these therapies.

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PII: 8242