Oncotarget

Research Papers:

Quantitative assessment of TIM-3 polymorphisms and cancer risk in Chinese Han population

Xueren Gao, Jiaojiao Yang, Youji He and Jianqiong Zhang _

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Oncotarget. 2016; 7:35768-35775. https://doi.org/10.18632/oncotarget.8157

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Abstract

Xueren Gao1, Jiaojiao Yang1, Youji He1 and Jianqiong Zhang1,2

1 Department of Microbiology and Immunology, Medical School of Southeast University, Nanjing, Jiangsu, China

2 Jiangsu Key Laboratory of Molecule Imaging and Functional Imaging, Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Medical School of Southeast University, Nanjing, Jiangsu, China

Correspondence to:

Jianqiong Zhang, email:

Keywords: TIM-3, polymorphism, cancer

Received: December 16, 2015 Accepted: March 04, 2016 Published: March 17, 2016

Abstract

Previous studies have investigated the associations of TIM-3 polymorphisms (-1516G/T, -574G/T, and +4259T/G) with cancer risk in Chinese Han population, but the results remain conflicting. Therefore, we conducted a meta-analysis to derive a more precise estimation of the associations. The pooled data showed that TIM-3 polymorphisms (-1516G/T, -574G/T, and +4259T/G) were significantly associated with an increased risk of overall cancer in Chinese Han population. Subgroup analyses based on cancer system showed that TIM-3 -1516G/T polymorphism was only associated with an increased risk of digestive system cancer in Chinese Han population. TIM-3 -574G/T polymorphism was associated with an increased risk of digestive system cancer and other cancer in Chinese Han population. TIM-3 +4259T/G polymorphism was only associated with an increased risk of other cancer in Chinese Han population. In summary, our results indicated that TIM-3 polymorphisms (-1516G/T, -574G/T, and +4259T/G) were associated with the increased risk of cancer in Chinese Han population.


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