The altered glucose metabolism in tumor and a tumor acidic microenvironment associated with extracellular matrix metalloproteinase inducer and monocarboxylate transporters
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Xiaofeng Li1,2,3, Xiaozhou Yu1,2,3, Dong Dai1,2,3, Xiuyu Song1,2,3 and Wengui Xu1,2,3
1 Department of Molecular Imaging and Nuclear Medicine, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
2 National Clinical Research Center for Cancer, Tianjin, China
3 Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
Wengui Xu, email:
Keywords: extracellular matrix metalloproteinase inducer, monocarboxylate transporters, glycolysis, tumor acidic microenvironment, p53
Received: July 30, 2015 Accepted: January 13, 2016 Published: March 17, 2016
Extracellular matrix metalloproteinase inducer, also knowns as cluster of differentiation 147 (CD147) or basigin, is a widely distributed cell surface glycoprotein that is involved in numerous physiological and pathological functions, especially in tumor invasion and metastasis. Monocarboxylate transporters (MCTs) catalyze the proton-linked transport of monocarboxylates such as L-lactate across the plasma membrane to preserve the intracellular pH and maintain cell homeostasis. As a chaperone to some MCT isoforms, CD147 overexpression significantly contributes to the metabolic transformation of tumor. This overexpression is characterized by accelerated aerobic glycolysis and lactate efflux, and it eventually provides the tumor cells with a metabolic advantage and an invasive phenotype in the acidic tumor microenvironment. This review highlights the roles of CD147 and MCTs in tumor cell metabolism and the associated molecular mechanisms. The regulation of CD147 and MCTs may prove to be with a therapeutic potential for tumors through the metabolic modification of the tumor microenvironment.
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