Oncotarget

Research Papers:

High expression of C-C chemokine receptor 2 associates with poor overall survival in gastric cancer patients after surgical resection

Ruochen Li _, Heng Zhang, Hao Liu, Chao Lin, Yifan Cao, Weijuan Zhang, Zhenbin Shen and Jiejie Xu

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Oncotarget. 2016; 7:23909-23918. https://doi.org/10.18632/oncotarget.8069

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Abstract

Ruochen Li1,*, Heng Zhang2,*, Hao Liu2,*, Chao Lin2, Yifan Cao1, Weijuan Zhang3, Zhenbin Shen2, Jiejie Xu1

1Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China

2Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

3Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China

*These authors have contributed equally to this work

Correspondence to:

Zhenbin Shen, email: shen.zhenbin@zs-hospital.sh.cn

Jiejie Xu, email: jjxufdu@fudan.edu.cn

Keywords: gastric cancer, CCR2, overall survival, prognosis, biomarker

Received: November 01, 2015     Accepted: February 28, 2016     Published: March 14, 2016

ABSTRACT

Background: Being a critical chemokine receptor in chemoattracting myeloid cells into tumor tissues, C-C chemokine receptor 2 (CCR2) has been detected in many malignant tumors. This study aims to evaluate the prognostic value of CCR2 expression in patients with gastric cancer after surgery.

Results: CCR2 expression was detected in the accessory cells around gastric cancer cells in a diffused manner. CCR2 high expression was correlated with tumor invasion depth (P=0.006 and P=0.004, respectively), lymph node metastasis (P=0.038 and P=0.011, respectively) and TNM stage (P=0.003 and P=0.001, respectively) in the two independent sets. Multivariate Cox regression analysis identifies CCR2 high expression was an independent poor prognostic factor for OS of patients with gastric cancer in the two sets (P=0.013 and P=0.006, respectively). Integration of CCR2 expression and TNM stage could provide additional prognostic value for OS than TNM stage alone in the two sets (P=0.038 and P=0.002, respectively).

Methods: Two independent sets comprising a total of 474 patients who received standard gastrectomy were enrolled in the study. The expression level of CCR2 was detected by immunohistochemistry. The correlations between CCR2 expression and clinicopathological factors were explored, and the prognostic significance for overall survival (OS) was determined by Kaplan-Meier analysis.

Conclusions: CCR2 high expression in the tumor microenvironment is a novel independent unfavorable prognostic factor for patients with gastric cancer. Combination of CCR2 expression and TNM stage could provide a better prognostic model for OS of gastric cancer patients.


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