Oncotarget

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MicroRNAs mediated regulation of MAPK signaling pathways in chronic myeloid leukemia

Chiranjib Chakraborty _, Ashish Ranjan Sharma, Bidhan Chandra Patra, Manojit Bhattacharya, Garima Sharma and Sang-Soo Lee

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Oncotarget. 2016; 7:42683-42697. https://doi.org/10.18632/oncotarget.7977

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Abstract

Chiranjib Chakraborty1,2,*, Ashish Ranjan Sharma1,*, Bidhan Chandra Patra3,*, Manojit Bhattacharya1,3,*, Garima Sharma1, Sang-Soo Lee1

1Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon, 200704, Korea

2Department of Bio-informatics, School of Computer and Information sciences, Galgotias University, Greater Noida, Uttar Pradesh, 203201, India

3Aquaculture Research Unit, Department of Zoology, Vidyasagar University, Midnapore, West Bengal, 721102, India

*These authors have contributed equally to this work

Correspondence to:

Sang-Soo Lee, email: totalhip@hallym.ac.kr; 123sslee@gmail.com

Chiranjib Chakraborty, email: drchiranjib@yahoo.com

Keywords: chronic myeloid leukemia, microRNA, signaling pathway, oncogenic, MAPK

Received: October 02, 2015     Accepted: February 20, 2016     Published: March 8, 2016

ABSTRACT

Chronic myeloid leukemia (CML) is a severe problem throughout the world and requires identification of novel targets for its treatment. This multifactorial disease accounts for about 15% of the all diagnosed leukemia cases. Mitogen-activated protein kinase (MAPK) signaling pathway is crucial for the cell survival and its dysregulation is being implicated in various types of cancers. In here, we have discussed the potential role of various miRNAs that are found involved in regulating the proteins cascades of MAPK signaling pathway associated with CML. An emphasis has been paid to summarize the influence of various miRNAs in elevating or suppressing the expression level of significant proteins such as miR-203, miR-196a, miR-196b, miR-30a, miR-29b, miR-138 in BCR-ABL tyrosine kinase; miR-126, miR-221, miR-128, miR-15a, miR-188-5p, miR-17 in CRK family proteins; miR-155, miR-181a with SOS proteins; miR-155, miR-19a, with KRAS proteins; miR-19a with RAF1 protein; and miR-17, miR-19a, miR-17-92 cluster with MAPK/ERK proteins. In light of ever-increasing importance and ever-widening regulatory roles of miRNAs in cells, we have reviewed the recent progress in the field of miRNAs and have tried to suggest them as controlling targets for various protein cascades of MAPK signaling pathway. An understanding of the supervisory mechanism of MAPK by miRNAs might provide novel targets for treating CML.


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