Oncotarget

Research Papers:

The preclinical study of predicting radiosensitivity in human nasopharyngeal carcinoma xenografts by 18F-ML-10 animal- PET/CT imaging

Xiao Bao, Zhongyi Yang, Siyang Wang, Yujia Zheng, Mingwei Wang, Bingxin Gu, Jianping Zhang, Yongping Zhang and Yingjian Zhang _

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Oncotarget. 2016; 7:20743-20752. https://doi.org/10.18632/oncotarget.7868

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Abstract

Xiao Bao1,2,3,4,*, Zhongyi Yang1,2,3,4,*, Siyang Wang1,2,3,4, Yujia Zheng1,2,3,4, Mingwei Wang1,2,3,4, Bingxin Gu1,2,3,4, Jianping Zhang1,2,3,4, Yongping Zhang1,2,3,4, Yingjian Zhang1,2,3,4

1Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai 200032, China

2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China

3Center for Biomedical Imaging, Fudan University, Shanghai 200032, China

4Shanghai Engineering Research Center for Molecular Imaging Probes, Shanghai 200032, China

*These authors have contributed equally to this work

Correspondence to:

Yingjian Zhang, e-mail: [email protected]

Keywords: nasopharyngeal carcinoma, nude mouse, 18F-ML-10, animal-PET/CT, irradiation sensitivity

Received: June 19, 2015    Accepted: February 16, 2016    Published: March 03, 2016

ABSTRACT

Previous studies have reported that the radiosensitivity is associated with apoptosis. Hereby, we aimed to investigate the value of 18F-ML-10 PET/CT, which selectively targeted cells undergoing apoptosis, in predicting radiosensitivity of human nasopharyngeal carcinoma (NPC) xenografts. We used CNE1 (highly differentiated) and CNE2 (poorly differentiated) NPC cell lines to construct tumor models, which had very different radiosensitivities. After irradiation, the volumes of CNE2 tumors decreased significantly while those of CNE1 tumors increased. In 18F-ML-10 imaging, the values of tumor/muscle (T/M) between CNE1 and CNE2 mice were statistically different at both 24 h and 48 h after irradiation. Besides, ΔT/M1-0 and ΔT/M2-0 of CNE2 mice were higher than those of CNE1 mice, demonstrating obvious discrepancy. Furthermore, we observed obvious changes of radioactive distribution in CNE2 group. On the contrary, T/M of 18F-FDG in irradiation group revealed no obvious change in both CNE1 and CNE2 groups. In conclusion, 18F-ML-10 animal PET/CT showed its potential to predict radiosensitivity in NPC.


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