Oncotarget

Research Papers:

Amplexicaule A exerts anti-tumor effects by inducing apoptosis in human breast cancer

Meixian Xiang, Hanwen Su, Guangwen Shu, Dingrong Wan, Feng He, Morgann Loaec, Yali Ding, Jun Li, Sinisa Dovat, Gaungzhong Yang _ and Chunhua Song

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Oncotarget. 2016; 7:18521-18530. https://doi.org/10.18632/oncotarget.7848

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Abstract

Meixian Xiang1,2,*, Hanwen Su3,*, Guangwen Shu1, Dingrong Wan1, Feng He1, Morgann Loaec2, Yali Ding2, Jun Li1, Sinisa Dovat2, Gaungzhong Yang1, Chunhua Song2

1College of Pharmacy, South-Central University for Nationalities, Wuhan, PR China

2Pennsylvania State University College of Medicine, Department of Pediatrics, Hershey, PA, USA

3Renmin Hospital of Wuhan University, Wuhan, PR China

*These authors contributed equally to this work

Correspondence to:

Guangzhong Yang, e-mail: 756626131@qq.com

Chunhua Song, e-mail: csong@hmc.psu.edu

Keywords: amplexicaule A, apoptosis, Akt/mTOR, MCL-1, breast cancer

Received: September 02, 2015     Accepted: January 18, 2016     Published: March 02, 2016

ABSTRACT

Chemotherapy is the main treatment for patients with breast cancer metastases, but natural alternatives have been receiving attention for their potential as novel anti-tumor reagents. Amplexicaule A (APA) is a flavonoid glucoside isolated from rhizomes of Polygonum amplexicaule D. Don var. sinense Forb (PADF). We found that APA has anti-tumor effects in a breast cancer xenograft mouse model and induces apoptosis in breast cancer cell lines. APA increased levels of cleaved caspase-3,-8,-9 and PARP, which resulted from suppression of MCL-1 and BCL-2 expression in the cells. APA also inactivated the Akt/mTOR pathway in breast cancer cells. Thus, APA exerts a strong anti-tumor effect on breast cancer cells, most likely through induction of apoptosis. Our study is the first to identify this novel anti-tumor compound and provides a new strategy for isolation and separation of single compounds from herbs.


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