Oncotarget

Research Papers:

Lymph nodes regression grade is a predictive marker for rectal cancer after neoadjuvant therapy and radical surgery

Jun Li _, Jiatian Yuan, Hao Liu, Jie Yin, Sai Liu, Feng Du, Junjie Hu, Ci Li, Xiangke Niu, Bo Lv and Shasha Xing

PDF  |  HTML  |  How to cite  |  Order a Reprint

Oncotarget. 2016; 7:16975-16984. https://doi.org/10.18632/oncotarget.7703

Metrics: PDF 685 views  |   HTML 1026 views  |   ?  


Abstract

Jun Li1, Jiatian Yuan1, Hao Liu2, Jie Yin3, Sai Liu4, Feng Du5, Junjie Hu6, Ci Li7, Xiangke Niu8, Bo Lv1, Shasha Xing9

1General Surgery Department, Affiliated Hospital/Clinical Medical College of Chengdu University, Chengdu, P.R. China

2General Surgery Department, Second Affiliated Hospital of Jilin University, Changchun, P.R. China

3General Surgery Department, Xuzhou Central Hospital, Xuzhou, P.R. China

4Surgical Department of Gastrointestinal Diseases, Beijing Youan Hospital of Capital Medical University, Beijing, P.R. China

5Internal Medicine-Oncology, Cancer Institute/Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, P.R. China

6Gastrointestinal Tumor Surgery, Hubei Cancer Hospital, Wuhan, P.R. China

7Department of Pathology, Affiliated Hospital/Clinical Medical College of Chengdu University, Chengdu, P.R. China

8Department of Radiology, Affiliated Hospital/Clinical Medical College of Chengdu University, Chengdu, P.R. China

9Central Lab, Affiliated Hospital/Clinical Medical College of Chengdu University, Chengdu, P.R. China

Correspondence to:

Jun Li, e-mail: junl_paper@sina.com

Jiatian Yuan, e-mail: jiatianyuan_pro@sina.com

Shasha Xing, e-mail: xingshasha1230@126.com

Keywords: lymph node, regression grading, rectal cancer, neoadjuvant therapy

Received: October 10, 2015    Accepted: February 08, 2016    Published: February 25, 2016

ABSTRACT

Neoadjuvant therapy (NT) for rectal cancer (RC) reduces primary tumors and involved lymph nodes. While a prognostic value of tumor regression grade (TRG) has been identified, involved lymph node regression grade (LRG) has not been systematically evaluated. Here, we evaluated the association of LRG with oncologic outcomes of RC patients after NT followed by radical surgery. 347 patients with locally advanced RC who received NT and then underwent radical surgery were retrospectively recruited between 2004 and 2011. Response to NT was evaluated by a 3-tier LRG and TRG based on the ratio of residual tumor to fibrosis. LRG was assessed in all patients (LRG 0, 170 patients [49.0%]; LRG 1, 100 patients [28.8%]; and LRG 2, 77 patients [22.2%]). LRG correlated with 5-year distant metastasis and 5-year disease free survival (p=0.029 and 0.023, respectively). LRG also correlated with TRG (p=0.017). We conclude that the LRG system may be an independent predictive factor of long-term oncologic outcomes of rectal cancer patients after NT and radical surgery.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
PII: 7703