Comprehensive analysis of lncRNA expression profiles and identification of functional lncRNAs in lung adenocarcinoma
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Mantang Qiu1,2,*, Dongjie Feng1,*, Haitian Zhang1,3,*, Wenjia Xia1,2, Youtao Xu1, Jie Wang1,4, Gaochao Dong1,4, Yewei Zhang5, Rong Yin1 and Lin Xu1
1 Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Nanjing, China
2 The Fourth Clinical College of Nanjing Medical University, Nanjing, China
3 The First Clinical Medical College of Nanjing Medical University, Nanjing, China
4 Department of Scientific Research, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, China
5 Department of General Surgery, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, China
* These authors have contributed equally to this work
Lin Xu, email:
Rong Yin, email:
Keywords: lung adenocarcinoma, lncRNA, expression profile, LCAL6
Received: September 20, 2015 Accepted: February 07, 2016 Published: February 21, 2016
Increasing evidence has highlighted the critical roles of long non-coding RNAs (lncRNAs) as biomarkers and therapeutic targets for cancer. Here, we characterized lncRNA expression profile in lung adenocarcinoma (LUAD). A training-validation method was applied to identify differentially expressed lncRNAs between LUAD samples and normal samples. 856 differentially expressed lncRNAs were identified. Bioinformatics analyses showed that these lncRNAs were located nearby transcription start sites and key regulators of cancer and these lncRNAs were involved in many critical biological processes. We found the lung cancer associated lncRNA 6 (LCAL6) was significantly unregulated and predicted survival in LUAD. Silence of LCAL6 inhibited LUAD tumor cell growth both in vitro and in vivo. To summary, we comprehensively analyze lncRNA expression profile in LUAD and provide resources for further search for clinical biomarkers and therapeutic targets of LUAD.
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