Oncotarget

Research Papers:

Genetic variant rs4072037 of MUC1 and gastric cancer risk in an Eastern Chinese population

Li-Xin Qiu, Rui-Xi Hua, Lei Cheng, Jing He, Meng-Yun Wang, Fei Zhou, Xiao-Dong Zhu, Meng-Hong Sun, Xiao-Yan Zhou, Jin Li, Ya-Nong Wang, Ya-Jun Yang, Jiu-Cun Wang, Li Jin, Wei-Jian Guo and Qing-Yi Wei _

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Oncotarget. 2016; 7:15930-15936. https://doi.org/10.18632/oncotarget.7527

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Abstract

Li-Xin Qiu1,2,*, Rui-Xi Hua3,*, Lei Cheng2,*, Jing He4, Meng-Yun Wang2, Fei Zhou2, Xiao-Dong Zhu1, Meng-Hong Sun5, Xiao-Yan Zhou5, Jin Li1, Ya-Nong Wang6, Ya-Jun Yang7,8, Jiu-Cun Wang7,8, Li Jin7,8, Wei-Jian Guo1, Qing-Yi Wei2,9

1Department of Medical Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China

2Cancer Institute, Collaborative Innovation Center for Cancer Medicine, Fudan University Shanghai Cancer Center, Shanghai, China

3Department of Oncology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

4Department of Pediatric Surgery, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China

5Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China

6Department of Gastric Cancer and Soft Tissue Sarcoma Surgery, Fudan University Shanghai Cancer Center, Shanghai, China

7Ministry of Education Key Laboratory of Contemporary Anthropology and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China

8Fudan-Taizhou Institute of Health Sciences, Taizhou, Jiangsu, China

9Duke Cancer Institute, Duke University Medical Center and Department of Medicine, Duke University School of Medicine, Durham, NC, USA

*These authors contributed equally to this work

Correspondence to:

Wei-Jian Guo, e-mail: guoweijian1@sohu.com

Qing-Yi Wei, e-mail: weiqingyi@yahoo.com and qingyi.wei@duke.edu

Keywords: gastric cancer, genetic susceptibility, MUC1, polymorphism

Received: November 22, 2015     Accepted: February 09, 2016     Published: February 20, 2016

ABSTRACT

Published data on the association between the MUC1 rs4072037A > G polymorphism and gastric cancer (GCa) risk were inconclusive. To derive a more precise estimation of the association, we conducted a large GCa study of 1,124 cases and 1,192 controls to confirm this association in an Eastern Chinese population. Our results showed that the G allele was strongly associated with a decreased GCa risk in the study population [GG vs. AA, odds ratio (OR) = 0.47, 95% confidence interval (CI) = 0.31–0.73; AG/GG vs. AA, OR = 0.82, 95% CI = 0.68–0.99; GG vs. AA/AG, OR = 0.48, 95% CI = 0.32–0.74]. These associations remained significant in subgroups of age, tumor site, drinking and smoking status. Moreover, this association was supported by an additional meta-analysis of published studies. In summary, these results suggest that the MUC1 rs4072037G allele may be a low-penetrating protection factor for GCa risk in Chinese populations.


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