Genetic variant rs4072037 of MUC1 and gastric cancer risk in an Eastern Chinese population
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Li-Xin Qiu1,2,*, Rui-Xi Hua3,*, Lei Cheng2,*, Jing He4, Meng-Yun Wang2, Fei Zhou2, Xiao-Dong Zhu1, Meng-Hong Sun5, Xiao-Yan Zhou5, Jin Li1, Ya-Nong Wang6, Ya-Jun Yang7,8, Jiu-Cun Wang7,8, Li Jin7,8, Wei-Jian Guo1, Qing-Yi Wei2,9
1Department of Medical Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
2Cancer Institute, Collaborative Innovation Center for Cancer Medicine, Fudan University Shanghai Cancer Center, Shanghai, China
3Department of Oncology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
4Department of Pediatric Surgery, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China
5Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China
6Department of Gastric Cancer and Soft Tissue Sarcoma Surgery, Fudan University Shanghai Cancer Center, Shanghai, China
7Ministry of Education Key Laboratory of Contemporary Anthropology and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China
8Fudan-Taizhou Institute of Health Sciences, Taizhou, Jiangsu, China
9Duke Cancer Institute, Duke University Medical Center and Department of Medicine, Duke University School of Medicine, Durham, NC, USA
*These authors contributed equally to this work
Wei-Jian Guo, e-mail: firstname.lastname@example.org
Keywords: gastric cancer, genetic susceptibility, MUC1, polymorphism
Received: November 22, 2015 Accepted: February 09, 2016 Published: February 20, 2016
Published data on the association between the MUC1 rs4072037A > G polymorphism and gastric cancer (GCa) risk were inconclusive. To derive a more precise estimation of the association, we conducted a large GCa study of 1,124 cases and 1,192 controls to confirm this association in an Eastern Chinese population. Our results showed that the G allele was strongly associated with a decreased GCa risk in the study population [GG vs. AA, odds ratio (OR) = 0.47, 95% confidence interval (CI) = 0.31–0.73; AG/GG vs. AA, OR = 0.82, 95% CI = 0.68–0.99; GG vs. AA/AG, OR = 0.48, 95% CI = 0.32–0.74]. These associations remained significant in subgroups of age, tumor site, drinking and smoking status. Moreover, this association was supported by an additional meta-analysis of published studies. In summary, these results suggest that the MUC1 rs4072037G allele may be a low-penetrating protection factor for GCa risk in Chinese populations.
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