Meta-analysis of the association between selenium and gastric cancer risk
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He-Yi Gong1,*, Jin-Guang He2,*, Bao-Sheng Li3
1Department of Radiation Oncology, Key Laboratory of Radiation Oncology of Shandong Province, Shandong Cancer Hospital and Institute, Jinan 250117, Shandong, P.R. China
2Department of Oncology, Heze Municiple Hospital, Heze 274031, Shandong, P.R. China
3Department of Radiation Oncology, Key Laboratory of Radiation Oncology of Shandong Province, Shandong Cancer Hospital and Institute, Jinan 250117, Shandong, P.R. China
*These authors contributed equally to this work
Bao-Sheng Li, e-mail: [email protected]
Keywords: gastric cancer, selenium, mortality, association, meta-analysis
Received: September 03, 2015 Accepted: January 09, 2016 Published: February 05, 2016
To clarify the effects of selenium level on the risk of gastric cancer (GC) and GC mortality, a meta-analysis was performed. Related studies were identified from PubMed, EMBASE, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure (CNKI), and Chinese Biology Medicine (CBM). Pooled ORs and 95% CIs were used to assess the strengthof the associations. A total of 8 studies including 17834 subjects were involved in this meta-analysis. High selenium level was associated with GC risk in case-control study (OR = 0.62, 95% CI 0.44–0.89, P = 0.009; I2 = 52%) and cohort study (OR = 0.87, 95% CI 0.78–0.97, P = 0.01; I2 = 25%). In addition, high selenium level was associated with GC mortality risk (OR = 0.90, 95% CI 0.84–0.97, P = 0.006, I2 = 49%). In summary, this meta-analysis suggested that selenium might inversely associated with GC risk and GC mortality.
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