Oncotarget

Research Papers:

Phosphohistone H3 (pHH3) is a prognostic and epithelial to mesenchymal transition marker in diffuse gliomas

Ping Zhu, Chuan-Bao Zhang, Pei Yang, Jing Chen, Yu-Qing Liu, Hui-Min Hu, Hua Huang, Zhao-Shi Bao, Wei Zhang, Wei-Jia Kong and Tao Jiang _

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Oncotarget. 2016; 7:45005-45014. https://doi.org/10.18632/oncotarget.7154

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Abstract

Ping Zhu1,*, Chuan-Bao Zhang2,3,4,5,*, Pei Yang2,3,4,5, Jing Chen2, Yu-Qing Liu2, Hui-Min Hu2, Hua Huang2, Zhao-Shi Bao3,5, Wei Zhang3,5, Wei-Jia Kong1, Tao Jiang2,3,4,5

1Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China

2Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China

3Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China

4Center of Brain Tumor, Beijing Institute for Brain Disorders, Beijing 100069, China

5China National Clinical Research Center for Neurological Diseases, Beijing 100050, China

*These authors have contributed equally to this work

Correspondence to:

Tao Jiang, email: taojiang1964@163.com

Wei-Jia Kong, email: entwjkong@hust.edu.cn

Keywords: glioma, pHH3, prognosis, EMT

Received: August 23, 2015    Accepted: January 23, 2016    Published: February 03, 2016

ABSTRACT

The World Health Organization (WHO) grading of gliomas stratifies tumors by histology. However, the aggressiveness of tumors in each grade still shows great heterogeneity. Phosphohistone H3 (pHH3) has been reported as an accurate marker of cells within the mitotic phase of the cell cycle in many kinds of cancers. To evaluate the role of pHH3 in predicting patient outcome and to annotate the functions of pHH3 in WHO grade II-IV gliomas, we analyzed the expression pattern of pHH3 and pHH3 associated genes by IHC and mRNA expression profiling. Phosphohistone H3, mRNA enrichment of histone H3 and associated gene signature all showed prognostic value in adult diffuse gliomas. Gene set enrichment analysis suggested that the expression of pHH3 had positive correlation with both epithelial to mesenchymal transition and immune response. These findings suggest that subgroups of diffuse gliomas defined by pHH3 and pHH3 signatures possess distinctive prognostic and biological characteristics.


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