Evolving roles of circadian rhythms in liver homeostasis and pathology

Dexi Zhou, Yaqin Wang, Lu Chen, Leijuan Jia, Jie Yuan, Mei Sun, Wen Zhang, Peipei Wang, Jian Zuo, Zhenyu Xu and Jiajie Luan _

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Oncotarget. 2016; 7:8625-8639. https://doi.org/10.18632/oncotarget.7065

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Dexi Zhou1,2,*, Yaqin Wang1,2,*, Lu Chen1,2, Leijuan Jia1,2, Jie Yuan1,2, Mei Sun1,2, Wen Zhang1,2, Peipei Wang1,2, Jian Zuo1,2, Zhenyu Xu1,2, Jiajie Luan1,2

1 Laboratory of Clinical Pharmacy of Wannan Medical College, Wuhu, Anhui Province, China

2 Department of Pharmacy in Yijishan Hospital of Wannan Medical College, Wuhu, Anhui Province, China

* The authors have contributed equally to this paper

Correspondence to:

Jiajie Luan, email:

Dexi Zhou, email:

Keywords: circadian rhythms, liver metabolism, epigenetic modifications, liver fibrosis, hepatocellular carcinoma

Received: October 14, 2015 Accepted: January 18, 2016 Published: January 28, 2016


Circadian clock in mammals is determined by a core oscillator in the suprachiasmatic nucleus (SCN) of the hypothalamus and synchronized peripheral clocks in other tissues. The coherent timing systems could sustain robust output of circadian rhythms in response to the entrainment controlled environmentally. Disparate approaches have discovered that clock genes and clock-controlled genes (CCGs) exist in nearly all mammalian cell types and are essential for establishing the mechanisms and complexity of internal time-keeping systems. Accumulating evidence demonstrates that the control of homeostasis and pathology in the liver involves intricate loops of transcriptional and post-translational regulation of clock genes expression. This review will focus on the recent advances with great importance concerning clock rhythms linking liver homeostasis and diseases. We particularly highlight what is currently known of the evolving insights into the mechanisms underlying circadian clock . Eventually , findings during recent years in the field might prompt new circadian-related chronotherapeutic strategies for the diagnosis and treatment of liver diseases by coupling these processes

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