Research Papers: Immunology:

The role of TRPV1 in the CD4+ T cell-mediated inflammatory response of allergic rhinitis

Ramachandran Samivel, Dae Woo Kim, Hye Ran Son, Yun-Hee Rhee, Eun Hee Kim, Ji Hye Kim, Jun-Sang Bae, Young-Jun Chung, Phil-Sang Chung, Eyal Raz and Ji-Hun Mo _

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Oncotarget. 2016; 7:148-160. https://doi.org/10.18632/oncotarget.6653

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Ramachandran Samivel1,2,*, Dae Woo Kim3,6,*, Hye Ran Son1, Yun-Hee Rhee2, Eun Hee Kim1,2, Ji Hye Kim1,2, Jun-Sang Bae2,4, Young-Jun Chung1,2, Phil-Sang Chung1,2, Eyal Raz5 and Ji-Hun Mo1,2,6

1 Department of Otorhinolaryngology, Dankook University College of Medicine, Cheonan, South Korea

2 Beckman Laser Institute Korea, Dankook University College of Medicine, Cheonan, South Korea

3 Department of Otorhinolaryngology-Head and Neck Surgery, Boramae Medical Center, Seoul National University College of Medicine, Seoul, South Korea

4 Department of Premedical Course, Dankook University College of Medicine, Cheonan, South Korea

5 Department of Medicine, University of California, San Diego, La Jolla, California, USA

6 Clinical Mucosal Immunology Study Group

* These auhtors have contributed equally to this work

Correspondence to:

Ji-Hun Mo, email:

Keywords: allergic rhinitis, BCTC, CD4 T lymphocyte, OVA, TRPV1, Immunology and Microbiology Section, Immune response, Immunity

Received: July 21, 2015 Accepted: November 21, 2015 Published: December 18, 2015


Transient receptor potential vanilloid 1 (TRPV1), which has been identified as a molecular target for the activation of sensory neurons by various painful stimuli, was reported to regulate the signaling and activation of CD4+ T cells. However, the role of TRPV1 in CD4+ T cell in allergic rhinitis remains poorly understood. In this study, TRPV1 expression was localized in CD4+ T cells. Both knockout and chemical inhibition of TRPV1 suppressed Th2/Th17 cytokine production in CD4 T cells and Jurkat T cells, respectively, and can suppress T cell receptor signaling pathways including NF-κB, MAP kinase, and NFAT. In TRPV1 knockout allergic rhinitis (AR) mice, eosinophil infiltration, Th2/Th17 cytokines in the nasal mucosa, and total and ova-specific IgE levels in serum decreased, compared with wild-type AR mice. The TRPV1 antagonists, BCTC or theobromine, showed similar inhibitory immunologic effects on AR mice models. In addition, the number of TRPV1+/CD4+ inflammatory cells increased in the nasal mucosa of patients with AR, compared with that of control subjects. Thus, TRPV1 activation on CD4+ T cells is involved in T cell receptor signaling, and it could be a novel therapeutic target in AR.

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