Research Papers:

Prognostic value of high EZH2 expression in patients with different types of cancer: a systematic review with meta-analysis

Tao Jiang, Yan Wang, Fei Zhou, Guanghui Gao, Shengxiang Ren and Caicun Zhou _

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Oncotarget. 2016; 7:4584-4597. https://doi.org/10.18632/oncotarget.6612

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Tao Jiang1, Yan Wang1, Fei Zhou1, Guanghui Gao1, Shengxiang Ren1, Caicun Zhou1

1Department of Medical Oncology, Shanghai Pulmonary Hospital, Thoracic Cancer Institute, Tongji University School of Medicine, Shanghai, 200433, P.R. China

Correspondence to:

Caicun Zhou, e-mail: [email protected]

Keywords: enhancer of zeste homologue 2, cancer, prognosis, systematic review, meta-analysis

Received: September 11, 2015     Accepted: November 26, 2015     Published: December 14, 2015


Enhancer of zeste homologue 2 (EZH2) is a potential independent mechanism for epigenetic silencing of tumor suppressor genes in cancer. We conducted an electronic search on PubMed, EMBASE, Web of Science, and Cochrane library to perform this up-to-date meta-analysis. Fifty-one studies with a total of 9444 patients were included. The prevalence of high EZH2 expression was 0.54 (95% CI: 0.47-0.61). High EZH2 expression was significantly associated with poorer prognosis [overall survival: HR 1.54 (95% CI: 1.30-1.78), P < 0.000; disease free survival: HR 1.35 (95% CI: 1.00-1.71), P < 0.000]. In breast cancer, high EZH2 expression correlated with histological types [OR: 1.53 (95CI: 1.13-2.06); P < 0.006], histological grade [OR: 1.62 (95CI: 1.35-1.95); P < 0.000], estrogen receptor (ER) negativity [OR: 2.05 (95CI: 1.67-2.52); P < 0.000], progesterone receptor (PgR) negativity [OR: 1.42 (95CI: 1.03-1.96); P = 0.034], HER-2 positivity [OR: 1.35 (95CI: 1.08-1.69); P = 0.009], and high p53 expression [OR: 1.66 (95CI: 1.07-2.59); P = 0.024]. These results suggest that high EZH2 expression may be a promising prognostic factor to different cancers. High EZH2 expression tends to correlate with pathological types, histological grade, ER negativity, PgR negativity, HER-2 positivity and p53 high expression in breast cancer.

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