Overexpression of HE4 (human epididymis protein 4) enhances proliferation, invasion and metastasis of ovarian cancer
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Liancheng Zhu1,*, Huiyu Zhuang1,2,*, Huimin Wang1, Mingzi Tan1, Carlton L. Schwab3, Lu Deng1, Jian Gao1, Yingying Hao1, Xiao Li1, Song Gao1, Juanjuan Liu1, Bei Lin1
1Department of Obstetrics and Gynecology, Shengjing Hospital Affiliated to China Medical University, Shenyang, Liaoning 110004, China
2Department of Obstetrics and Gynecology, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing 100043, China
3Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520–8063, USA
*These authors have contributed equally to this work
Bei Lin, e-mail: [email protected]
Keywords: HE4, epithelial ovarian cancer, proliferation, invasion, metastasis
Received: July 14, 2015 Accepted: October 30, 2015 Published: November 09, 2015
Overexpression of Human epididymis protein 4 (HE4) related with a role in ovarian cancer tumorigenesis while little is known about the molecular mechanism alteration by HE4 up regulation. Here we reported that overexpressed HE4 promoted ovarian cancer cells proliferation, invasion and metastasis. Furthermore, human whole genome gene expression profile microarrays revealed that 231 differentially expressed genes (DEGs) were altered in response to HE4, in which MAPK signaling, ECM receptor, cell cycle, steroid biosynthesis pathways were involved. The findings suggested that overexpressed HE4 played an important role in ovarian cancer progression and metastasis and that HE4 has the potential to serve as a novel therapeutic target for ovarian cancer.
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