The role of N-glycans in colorectal cancer progression: potential biomarkers and therapeutic applications
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Julio Cesar Madureira de Freitas Junior1 and José Andrés Morgado-Díaz1
1 Cellular Biology Program, Structural Biology Group, Brazilian National Cancer Institute (INCA), Rio de Janeiro, RJ, Brazil
Julio Cesar Madureira de Freitas Junior, email:
José Andrés Morgado-Díaz, email:
Keywords: N-glycans, colorectal cancer, biomarkers, glycosylation, carcinoma
Received: May 28, 2015 Accepted: October 22, 2015 Published: November 02, 2015
Changes in glycosylation, which is one of the most common protein post-translational modifications, are considered to be a hallmark of cancer. N-glycans can modulate cell migration, cell-cell adhesion, cell signaling, growth and metastasis. The colorectal cancer (CRC) is a leading cause of cancer-related mortality and the correlation between CRC progression and changes in the pattern of expression of N-glycans is being considered in the search for new biomarkers. Here, we review the role of N-glycans in CRC cell biology. The perspectives on emerging N-glycan-related anticancer therapies, along with new insights and challenges, are also discussed.
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