The miR-24-Bim pathway promotes tumor growth and angiogenesis in pancreatic carcinoma
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Rui Liu1, Haiyang Zhang1,2, Xia Wang1, Likun Zhou1, Hongli Li1, Ting Deng1, Yanjun Qu1, Jingjing Duan1, Ming Bai1, Shaohua Ge1, Tao Ning1, Le Zhang1, Dingzhi Huang1,* and Yi Ba1,*
1 Department of Gastrointestinal Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
2 State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
Yi Ba, email:
Dingzhi Huang, email:
Keywords: Bim, miR-24, pancreatic cancer, tumorigenesis, angiogenesis
Received: June 18, 2015 Accepted: October 08, 2015 Published: October 28, 2015
miRNAs are a group of small RNAs that have been reported to play a key role at each stage of tumorigenesis and are believed to have future practical value. We now demonstrate that Bim, which stimulates cell apoptosis, is obviously down-regulated in pancreatic cancer (PaC) tissues and cell lines. And Bim-related miR-24 is significantly up-regulated in PaC. The repressed expression of Bim is proved to be a result of miR-24, thus promoting cell growth of both cancer and vascular cells, and accelerating vascular ring formation. By using mouse tumor model, we clearly showed that miR-24 promotes tumor growth and angiogenesis by suppressing Bim expression in vivo. Therefore, a new pathway comprising miR-24 and Bim can be used in the exploration of drug-target therapy of PaC.
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