Genetic variant of PRKAA1 and gastric cancer risk in an eastern Chinese population
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Li-Xin Qiu1,2,*, Jing He3,*, Lei Cheng2,*, Fei Zhou2, Meng-Yun Wang2, Meng-Hong Sun4, Xiao-Yan Zhou4, Jin Li1, Wei-Jian Guo1, Ya-Nong Wang5, Ya-Jun Yang6,7, Jiu-Cun Wang6,7, Li Jin6,7, Xiao-Dong Zhu1, Qing-Yi Wei2,8
1Department of Medical Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
2Cancer Institute, Collaborative Innovation Center for Cancer Medicine, Fudan University Shanghai Cancer Center, Shanghai, China
3Department of Pediatric Surgery, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China
4Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China
5Department of Gastric Cancer and Soft Tissue Sarcoma Surgery, Fudan University Shanghai Cancer Center, Shanghai, China
6Ministry of Education Key Laboratory of Contemporary Anthropology and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China
7Fudan-Taizhou Institute of Health Sciences, Jiangsu, China
8Duke Cancer Institute, Duke University Medical Center, Durham, NC, USA
*These authors have contributed equally to this work
Xiao-Dong Zhu, e-mail: [email protected]
Keywords: PRKA71, polymorphism, gastric cancer, genetic susceptibility
Received: August 04, 2015 Accepted: October 09, 2015 Published: October 15, 2015
Published data on the association between PRKAA1 rs13361707 T > C polymorphism and gastric cancer (GCa) susceptibility were inconclusive. To derive a more precise estimation of the association, we conducted a large-scale GCa study of 1,124 cases and 1,194 controls to confirm this association in an eastern Chinese population. Our results showed that the C allele of PRKAA1 rs13361707 increased the GC risk in the study population [CT vs. TT, odds ratio (OR) = 1.72, 95% confidence interval (CI) = 1.40–2.12; CC vs. TT, OR = 2.15, 95%CI = 1.70–2.71; CT/CC vs. TT, OR = 1.86, 95%CI = 1.53–2.26; CC vs.TT/CT, OR = 1.49, 95%CI = 1.24–1.79]. In addition, the association of C allele with an increased GCa risk was still significant in subgroups, when stratified by age, sex, tumor site, drinking and smoking status. Moreover, the findings in the present study were validated by our further meta-analysis. In summary, these results indicated that the C allele of PRKAA1 rs13361707 was a low-penetrate risk factor for GCa.
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