Oncotarget

Clinical Research Papers:

Prognostic significance of the combination of preoperative hemoglobin, albumin, lymphocyte and platelet in patients with gastric carcinoma: a retrospective cohort study

Xiao-Long Chen _, Lian Xue, Wei Wang, Hai-Ning Chen, Wei-Han Zhang, Kai Liu, Xin-Zu Chen, Kun Yang, Bo Zhang, Zhi-Xin Chen, Jia-Ping Chen, Zong-Guang Zhou and Jian-Kun Hu

PDF  |  HTML  |  How to cite  |  Order a Reprint

Oncotarget. 2015; 6:41370-41382. https://doi.org/10.18632/oncotarget.5629

Metrics: PDF 2658 views  |   HTML 2433 views  |   ?  


Abstract

Xiao-Long Chen1,2,*, Lian Xue1,2,*, Wei Wang1,2,*, Hai-Ning Chen1,*, Wei-Han Zhang1,2, Kai Liu1,2, Xin-Zu Chen1,2, Kun Yang1,2, Bo Zhang1, Zhi-Xin Chen1, Jia-Ping Chen1, Zong-Guang Zhou1,3, Jian-Kun Hu1,2

1Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China

2Laboratory of Gastric Cancer, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China

3Laboratory of Digestive Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China

*These authors have contributed equally to this work

Correspondence to:

Jian-Kun Hu, e-mail: hujkwch@126.com

Keywords: gastric carcinoma, hemoglobin, albumin, lymphocyte, platelet

Received: July 04, 2015     Accepted: September 09, 2015     Published: October 15, 2015

ABSTRACT

Nutritional and immune status is important to the prognosis of patients with gastric carcinoma (GC). Here, we evaluated the prognostic significance of the combination of preoperative hemoglobin, albumin, lymphocyte and platelet (HALP) in patients with GC. From January 2005 to December 2011, 1332 patients with GC who underwent gastrectomy were randomly divided into the training (n = 888) and the validation sets (n = 444) by X-tile according to the sample size ratio 2:1. The cut-point of HALP was 56.8 and the patients were subsequently subdivided into HALP < 56.8 and HALP ≥ 56.8 groups in both two sets. Multivariate analysis revealed that gender (p < 0.001, p < 0.001), tumor size (p = 0.003, p = 0.035) and T stage (p < 0.001, p = 0.044) were independently related to HALP both in the training and the validation sets. Kaplan-Meier (p < 0.001, p = 0.003) and Cox regression (p = 0.043, p = 0.042) showed that the prognosis of HALP ≥ 56.8 group was significantly better than that of HALP < 56.8 group both in two sets (p < 0.001, p < 0.001). Nomograms of these two sets based on HALP was more accurate in prognostic prediction than TNM stage alone. Our findings suggested that HALP was closely associated with clinicopathological features and was an independent prognostic factor in GC patients. Nomogram based on HALP could accurately predict the prognosis of GC patients.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
PII: 5629