Clinical Research Papers:

Reducing the probability of radiation-induced hepatic toxicity by changing the treatment modality from helical tomotherapy to fixed-beam intensity-modulated radiotherapy

Jin Ho Song, Seok Hyun Son _, Chul Seung Kay and Hong Seok Jang

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Oncotarget. 2015; 6:33952-33960. https://doi.org/10.18632/oncotarget.5581

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Jin Ho Song1, Seok Hyun Son2, Chul Seung Kay2 and Hong Seok Jang3

1 Department of Radiation Oncology, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Korea

2 Department of Radiation Oncology, Incheon St. Mary’s Hospital, College of Medicine, the Catholic University of Korea, Seoul, Korea

3 Department of Radiation Oncology, Seoul St. Mary’s Hospital, College of Medicine, the Catholic University of Korea, Seoul, Korea

Correspondence to:

Seok Hyun Son, email:

Keywords: radiation-induced hepatic toxicity, hepatocellular carcinoma, helical tomotherapy, fixed-beam intensity-modulated radiotherapy

Received: June 24, 2015 Accepted: August 22, 2015 Published: September 10, 2015


Purpose: To estimate and compare the risk of radiation-induced hepatic toxicity (RIHT) in helical tomotherapy and fixed-beam intensity-modulated radiotherapy (IMRT) for the treatment of hepatocellular carcinoma (HCC).

Materials and Methods: Twenty patients with unresectable HCC treated with tomotherapy were selected. We performed tomotherapy re-planning to reduce the non-target normal liver volume receiving a dose of more than 15 Gy (NTNL-V15Gy), and we created a fixed-beam IMRT plan (FB-P). We compared the dosimetric results as well as the estimated probability of RIHT among the tomotherapy initial plan (T-IP), the tomotherapy re-plan (T-RP), and the FB-P.

Results:Comparing the T-RP and FB-P, the homogeneity index was 0.11 better with the T-RP. However, the mean NTNL-V15Gy was 6.3% lower with the FB-P. These differences result in a decline in the probability of RIHT from 0.216 in the T-RP to 0.115 in the FB-P. In patients whose NTNL-V15Gy was higher than 43.2% with the T-RP, the probability of RIHT markedly reduced from 0.533 to 0.274.

Conclusions: By changing the treatment modality from tomotherapy to fixed-beam IMRT, we could reduce the liver dose and the probability of RIHT without scarifying the target coverage, especially in patients whose liver dose is high.

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