Research Papers:

Dietary fatty acids intake and endometrial cancer risk: a dose-response meta-analysis of epidemiological studies

Qi-Jun Wu _, Ting-Ting Gong and Ya-Zhu Wang

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Oncotarget. 2015; 6:36081-36097. https://doi.org/10.18632/oncotarget.5555

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Qi-Jun Wu1, Ting-Ting Gong2, Ya-Zhu Wang3

1Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China

2Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China

3Department of Hematology, The First Affiliated Hospital of China Medical University, Shenyang, China

Correspondence to:

Qi-Jun Wu, e-mail: [email protected]

Ya-Zhu Wang, e-mail: [email protected]

Keywords: endometrial cancer, epidemiology, fatty acids, meta-analysis

Received: July 30, 2015     Accepted: September 25, 2015     Published: October 07, 2015


Epidemiological studies have provided controversial evidence of the association between dietary fatty acids intake and endometrial cancer risk. The continuous update project of World Cancer Research Fund failed to focus on this issue. To address this inconsistency, we conducted this dose-response meta-analysis based on epidemiological studies published up to the end of June 2015 identified from PubMed, EMBASE and Web of Science. Two authors independently performed the eligibility evaluation and data extraction. Random-effects models were used to estimate summary relative risks (RRs) and 95% confidence intervals (CIs). Fourteen epidemiological studies (4 cohort and 10 case-control studies) were included in this dose-response meta-analysis. The summary RR for an intake increment of 10g/day was 1.02 (95% CI = 0.97–1.08; I2 = 66.0%) for saturated fatty acids, 0.98 (95% CI = 0.96–1.001; I2 = 0%) for monounsaturated fatty acids, and 1.00 (95% CI = 0.95–1.06; I2 = 0%) for polyunsaturated fatty acids intake. Non-significant results were observed in the majority of subgroup analyses stratified by study characteristics and adjustment for potential confounders in analyses of aforementioned associations. In conclusion, results from this dose-response meta-analysis provided limited evidence that dietary saturated, monounsaturated, and polyunsaturated fatty acids consumption was associated with endometrial cancer risk. Further studies, especial prospective designed or pooled studies are warranted to confirm our findings.

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