Oncotarget

Clinical Research Papers:

Hepatic resection alone versus in combination with pre- and post-operative transarterial chemoembolization for the treatment of hepatocellular carcinoma: A systematic review and meta-analysis

Xingshun Qi _, Lei Liu, Diya Wang, Hongyu Li, Chunping Su and Xiaozhong Guo

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Oncotarget. 2015; 6:36838-36859. https://doi.org/10.18632/oncotarget.5426

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Abstract

Xingshun Qi1,*, Lei Liu2,*, Diya Wang3,*, Hongyu Li1, Chunping Su4, Xiaozhong Guo1

1Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang, China

2Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi’an, China

3Department of Occupational and Environmental Health Sciences and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, Xi’an, China

4Library of Fourth Military Medical University, Xi’an, China

*These authors have contributed equally to this work

Correspondence to:

Xiaozhong Guo, e-mail: guo_xiao_zhong@126.com

Xingshun Qi, e-mail: xingshunqi@126.com

Keywords: hepatocellular carcinoma, hepatic resection, transarterial chemoembolization, survival, recurrence

Received: June 13, 2015     Accepted: September 22, 2015     Published: October 05, 2015

ABSTRACT

Background and Aims: The prognosis of hepatocellular carcinoma (HCC) treated with hepatic resection may be improved by the adjunctive use of transarterial chemoembolization (TACE). This study aimed to systematically compare the outcomes between hepatic resection with and without TACE groups.

Methods: All relevant randomized controlled trials (RCTs) and non-RCTs were searched by the PubMed, EMBASE, and Cochrane Library databases. Overall survival (OS) and disease-free survival (DFS) were two major outcomes. Meta-analyses were performed according to the timing of TACE (pre- or post-operative TACE). Subgroup analyses were also performed. Hazard ratios (HRs) with 95% confidence intervals (95%CIs) were calculated.

Results: Overall, 55 papers were included (14 RCTs and 41 non-RCTs). Overall meta-analyses demonstrated that OS and DFS were statistically similar between hepatic resection with and without pre-operative TACE groups (HR = 1.01, 95%CI = 0.87–1.19, P = 0.87; HR = 0.91, 95%CI = 0.82–1.01, P = 0.07). Subgroup analyses of RCTs or non-RCTs showed that OS and DFS remained statistically similar between hepatic resection with and without pre-operative TACE groups. Subgroup analysis of incomplete or no tumor necrosis showed that OS was worse in hepatic resection with pre-operative TACE group than in hepatic resection without pre-operative TACE group. By contrast, subgroup analysis of complete tumor necrosis showed that DFS was better in hepatic resection with pre-operative TACE group than in hepatic resection without pre-operative TACE group.

Overall meta-analyses demonstrated that OS and DFS were better in hepatic resection with post-operative TACE group than in hepatic resection without post-operative TACE group (HR = 0.85, 95%CI = 0.72–1.00, P = 0.06; HR = 0.83, 95%CI = 0.73–0.94, P = 0.004). Subgroup analyses of RCTs, vascular invasion, or large HCC showed that OS and DFS remained better in hepatic resection with post-operative TACE group than in hepatic resection without post-operative TACE group. By contrast, subgroup analyses of non-RCTs, no vascular invasion, or small HCC showed that OS and DFS were statistically similar between the two groups.

Conclusions: Post-operative TACE, rather than pre-operative TACE, may be considered as an adjunctive treatment option for HCC treated with hepatic resection.


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