MiR-200b regulates autophagy associated with chemoresistance in human lung adenocarcinoma

Banzhou Pan; Bing Feng; Yitian Chen; Guichun Huang; Rui Wang; Longbang Chen; Haizhu Song

doi:10.18632/oncotarget.5352

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

MiR-200b regulates autophagy associated with chemoresistance in human lung adenocarcinoma

Banzhou Pan, Bing Feng, Yitian Chen, Guichun Huang, Rui Wang, Longbang Chen and Haizhu Song _

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2015; 6:32805-32820. https://doi.org/10.18632/oncotarget.5352

Metrics: PDF 1997 views | HTML 2676 views | ?

Abstract

Banzhou Pan1, Bing Feng1, Yitian Chen1, Guichun Huang1, Rui Wang1, Longbang Chen1,*, Haizhu Song1,*

1Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, China

*These authors have contributed equally to this work

Correspondence to:

Haizhu Song, e-mail: [email protected]

Keywords: miR-200b, autophagy, chemoresistance, human lung adenocarcinoma, ATG12

Received: April 12, 2015 Accepted: September 10, 2015 Published: September 21, 2015

ABSTRACT

Chemoresistance remains a major clinical problem in combating human lung adenocarcinoma (LAD), and abnormal autophagy is closely associated with this phenomenon. In the present study, an inverse correlation between miR-200b and autophagy-associated gene 12 (ATG12) expressions was observed in docetaxel-resistant (SPC-A1/DTX and H1299/DTX) and sensitive (SPC-A1 and H1299) LAD cells as well as in tissue samples. Further study showed that miR-200b directly targeted ATG12 in LAD. Moreover, miR-200b-dependent ATG12 downregulation inhibited autophagy and enhanced the chemosensitivity of SPC-A1/DTX and H1299/DTX cells both in vivo and in vitro. LAD chemoresistance is therefore closely related to downregulation of miR-200b and the corresponding upregulation of ATG12. These results provide new evidence for the mechanisms governing the microRNA (miRNA)-ATG12 network and their possible contribution to autophagy modulation and LAD chemoresistance.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 5352

Publication Alerts

Research Papers:

MiR-200b regulates autophagy associated with chemoresistance in human lung adenocarcinoma

Abstract