Clinical Research Papers:

Multibeam inverse intensity-modulated radiotherapy (IMRT) for whole breast irradiation: a single center experience in China

Zhaozhi Yang, Li Zhang, Xingxing Chen, Jinli Ma, Xin Mei, Jiayi Chen, Xiaoli Yu _ and Xiaomao Guo

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Oncotarget. 2015; 6:35063-35072. https://doi.org/10.18632/oncotarget.5278

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Zhaozhi Yang1,*, Li Zhang1,*, Xingxing Chen1,*, Jinli Ma1, Xin Mei1, Jiayi Chen2, Xiaoli Yu1, Xiaomao Guo1

1Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China

2Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

*These authors have contributed equally to this work

Correspondence to:

Xiaoli Yu, e-mail: [email protected]

Xiaomao Guo, e-mail: [email protected]

Keywords: breast cancer, radiotherapy, IMRT, whole breast irradiation, breast conservative treatment

Received: May 18, 2015     Accepted: September 04, 2015     Published: September 16, 2015


Purpose: To present the clinical experience in our cancer center with multibeam inverse intensity-modulated radiotherapy (IMRT) for early stage breast cancer (BC) patients with whole breast irradiation (WBI).

Methods: We retrospectively analyzed 622 patients with Stage 0 to III BC treated from 2008 to 2011 with wide local excision and WBI, using an inverse IMRT technique. All of the patients were prescribed a total dose of 50 Gy to the whole breast in 2-Gy fractions, followed by a tumor bed boost of 10 Gy in 5 fractions using an electron beam.

Results: Of all of the patients, 132 (21.2%) received whole breast plus regional lymph node (RLN) irradiation. 438 of 622 patients had records of acute skin toxicity based on common terminology criteria (CTC) for adverse events. Two hundred eighty (64%) patients had Grade 0/1 toxicity, 153 (35%) had Grade 2 and only 4 patients experienced grade 3 toxicity. Seventy patients (16%) had moist desquamation. Univariate analysis revealed that breast planning target volume was the only predictive factor for Grade ≥2 acute dermatitis (P = 0.002). After 4 years, 170 patients reported cosmetic results by self-assessment, of whom 151 (89%) patients reported good/excellent cosmetic results, and 17 (11%) patients reported fair assessments. For invasive cancer, the four-year rate of freedom from locoregional recurrence survival was 98.3%. Regarding carcinoma in situ, no patients experienced recurrence.

Conclusion: BC patients who underwent conservative surgery followed by inverse IMRT plan exhibited acceptable acute toxicities and clinical outcomes. Longer follow-up is needed.

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