Cyclotherapy: opening a therapeutic window in cancer treatment
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Ingeborg M.M. van Leeuwen1
1 Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
Ingeborg M.M. van Leeuwen, email:
Keywords: Cyclotherapy, chemotherapy, p53, nutlin-3, tenovin-6, leptomycin B, actinomycin D
Received: May 18, 2012, Accepted: June 15, 2012, Published: June 16, 2012
Cyclotherapy is a promising endeavor to improve cancer treatment by tackling the dose-limiting side effects of chemotherapy, especially for cancers harboring mutations in the TP53 tumor suppressor. In this particular context, pre-treatment with a p53 activator halts proliferation in healthy tissue, while leaving the p53-deficient tumor susceptible to conventional chemotherapy.
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