Research Papers: Gerotarget (Focus on Aging):
Splenocytes derived from young WT mice prevent AD progression in APPswe/PSENldE9 transgenic mice
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Fei Wang1,*, Xueyan Shen1,*, Shuping Li2,3,*, Long Chen1, Yanru Wang1, Jie Qin1, Guomin Zhou1, Yuwen Peng1, Xiaoyuan Feng2, Ruixi Li1, Chunmin Liang1
1Department of Anatomy and Histology & Embryology, Shanghai Medical College of Fudan University, Shanghai, P. R. China
2Department of Radiology, Huashan Hospital, Fudan University, Shanghai, P. R. China
3Department of Radiology, PLA No.455 Hospital, Shanghai, P. R. China
*These authors have contributed equally to this work
Chunmin Liang, e-mail: firstname.lastname@example.org
Keywords: Gerotarget, Alzheimer’s disease, splenocytes, immunosenescence, GDF11, Treg
Received: June 25, 2015 Accepted: July 24, 2015 Published: August 06, 2015
Immunosenescence contributes to pathogenesis of Alzheimer's disease (AD) in the elderly. In this study, we explored the effects of young wild type (WT) splenocytes (ySCs) on Alzheimer's disease by transplanting ySCs into APPswe/PSENldE9 transgenic mice. Young WT splenocytes not only prevented AD, but also improved the spatial learning and memory of APPswe/PSENldE9 transgenic mice. Young WT splenocytes enhanced Aβ clearance, decreased astrogliosis and increased systemic growth differentiation factor 11 (GDF11) levels. Splenocytes derived from old AD mouse promoted AD. There was an increased number of regulatory T cells (Tregs) among old AD splenocytes. We suggest that alterations of GDF11 and Tregs are involved in AD progression and that rejuvenation of the immune system is a potential therapeutic strategy in AD.
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