Research Perspectives:

NCI’s provocative questions on cancer: some answers to ignite discussion

Mikhail V. Blagosklonny _

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Oncotarget. 2011; 2:1352-1367. https://doi.org/10.18632/oncotarget.432

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Mikhail V. Blagosklonny1

1Department of Cell Stress Biology, Roswell Park Cancer Institute, BLSC, L3-312, Elm and Carlton Streets, Buffalo, NY, 14263, USA

Received: December 8, 2011; Accepted: December 31, 2011; Published: December 31, 2011;

Keywords: NCI, cancer, therapy, prevention, aging, rapamycin, mTOR


Mikhail V. Blagosklonny, email:


The National Cancer Institute has announced 24 provocative questions on cancer. Why do many cancer cells die when suddenly deprived of a protein encoded by an oncogene? Can we extend patient survival by using approaches that keep tumors static? Why are some disseminated cancers cured by chemotherapy alone? Can we develop methods to rapidly test interventions for cancer treatment or prevention? Can we use our knowledge of aging to enhance prevention or treatment of cancer? What is the mechanism by which some drugs commonly and chronically used for other indications protect against cancer? How does obesity contribute to cancer risk? Here I try to answer these questions by linking the dots of existing knowledge.

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