Research Perspectives:

Energy excess is the main cause of accelerated aging of mammals

Tomasz Biliński _, Tadeusz Paszkiewicz and Renata Zadrag-Tecza

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Oncotarget. 2015; 6:12909-12919. https://doi.org/10.18632/oncotarget.4271

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Tomasz Biliński1, Tadeusz Paszkiewicz2 and Renata Zadrag-Tecza1

1 Department of Biochemistry and Cell Biology, University of Rzeszow, Rzeszow, Poland

2 Retired from Rzeszów University of Technology, Rzeszow, Poland

Correspondence to:

Tomasz Biliński, email:

Keywords: aging, longevity, energy, glyco/lipotoxicity, epigenetic maintenance system

Received: May 18, 2015 Accepted: May 18, 2015 Published: May 26, 2015


The analysis of cases of unusually high longevity of naked mole rats and an alternative explanation of the phenomenon of calorie restriction effects in monkeys allowed for postulating that any factor preventing an excess of energy consumed, leads to increased lifespan, both in evolutionary and an individual lifetime scale. It is postulated that in mammals the most destructive processes resulting in shortening of life are not restricted to the phenomena explained by the hyperfunction theory of Mikhail Blagosklonny. Hyperfunction, understood as unnecessary or even adverse syntheses of cell components, can be to some extent prevented by lowered intake of nutrients when body growth ceases. We postulate also the contribution of glyco/lipotoxicity to aging, resulting from the excess of energy. Besides two other factors seem to participate in aging. One of them is lack of telomerase activity in some somatic cells. The second factor concerns epigenetic phenomena. Excessive activity of epigenetic maintenance system probably turns off some crucial organismal functions. Another epigenetic factor playing important role could be the micro RNA system deciding on expression of numerous age-related diseases. However, low extrinsic mortality from predation is a conditio sine qua non of the expression of all longevity phenotypes in animals. Among all long-lived animals, naked mole rats are unique in the elimination of neoplasia, which is accompanied by delayed functional symptoms of senescence. The question whether simultaneous disappearance of neoplasia and delayed senescence is accidental or not remains open.

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