Oncotarget

Research Papers:

Cynara scolymus affects malignant pleural mesothelioma by promoting apoptosis and restraining invasion

Claudio Pulito _, Federica Mori, Andrea Sacconi, Luca Casadei, Maria Ferraiuolo, Maria Cristina Valerio, Raffaela Santoro, Frauke Goeman, Anna Maidecchi, Luisa Mattoli, Cesare Manetti, Silvia Di Agostino, Paola Muti, Giovanni Blandino and Sabrina Strano

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Oncotarget. 2015; 6:18134-18150. https://doi.org/10.18632/oncotarget.4017

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Abstract

Claudio Pulito1, Federica Mori1, Andrea Sacconi2, Luca Casadei3, Maria Ferraiuolo2, Maria Cristina Valerio3, Raffaela Santoro1, Frauke Goeman2, Anna Maidecchi4, Luisa Mattoli4, Cesare Manetti3, Silvia Di Agostino2, Paola Muti5, Giovanni Blandino2,5, Sabrina Strano1,5

1Molecular Chemoprevention Unit, Molecular Medicine Area, Regina Elena National Cancer Institute, Rome, Italy

2Translational Oncogenomic Unit, Molecular Medicine Area, Regina Elena National Cancer Institute, Rome, Italy

3Department of Chemistry, University of Rome “La Sapienza”, Rome, Italy

4Aboca SpA Società Agricola, Sansepolcro, Italy

5Department of Oncology, Juravinski Cancer Center, McMaster University, Hamilton, Ontario, Canada

Correspondence to:

Sabrina Strano, e-mail: strano@ifo.it

Keywords: mesothelioma, tumorigenicity, invasion, pathway, apoptosis

Received: February 23, 2015     Accepted: June 12, 2015     Published: June 22, 2015

ABSTRACT

Malignant pleural mesothelioma is a poorly treated neoplasia arising from the pleural mesothelial lining. Here we document that the leaf extract of Cynara scolymus exerts broad antitumoral effects both in vitro and in vivo on mesothelioma cell lines. We found that Cynara scolymus treatment affects strongly cell growth, migration and tumor engraftment of mesothelioma cell lines. Strikingly, dietary feeding with Cynara scolymus leaf extract reduces the growth of mesothelioma xenografted tumors similarly to pemetrexed, a commonly employed drug in the treatment of mesothelioma. In aggregate our findings suggest that leaf extract of Cynara scolymus holds therapeutic potential for the treatment of mesothelioma.


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