Novel roles of TMEM100: inhibition metastasis and proliferation of hepatocellular carcinoma
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Dipeng Ou1,*, Hao Yang1,*, Dong Hua1, Shuai Xiao1 and Lianyue Yang2,3
1 Department of Geratic Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
2 Department of Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
3 Liver Cancer Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, China
* These authors have contributed equally to this work
Dipeng Ou, email:
Keywords: TMEM100; HCC; metastasis; proliferation; prognosis
Received: January 10, 2015 Accepted: April 08, 2015 Published: April 29, 2015
Transmembrane protein 100 (TMEM100) was activated by ALK1/TGF-β signaling. We found that TMEM100 was decreased in hepatocellular carcinoma (HCC) tissues and in highly metastatic cell lines. Overexpressed of TMEM100 inhibited invasion, migration and proliferation. Low levels of TMEM100 were associated with cirrhosis, tumor size, Tumor nodule number, TNM stage, BCLC stage, Edmondson-Steiner Stage and vein invasion. Furthermore, TMEM100 was an independent risk factor for overall survival (P = 0.03) and disease-free survival (P = 0.019). The current findings suggest that TMEM100 functions as a tumor suppressor in HCC metastasis and proliferation.
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