Clinical Research Papers:

Secondary bladder cancer after anticancer therapy for prostate cancer: reduced comorbidity after androgen-deprivation therapy

Masaki Shiota, Akira Yokomizo _, Ario Takeuchi, Kenjiro Imada, Keijiro Kiyoshima, Junichi Inokuchi, Katsunori Tatsugami, Saiji Ohga, Katsumasa Nakamura, Hiroshi Honda and Seiji Naito

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Oncotarget. 2015; 6:14710-14719. https://doi.org/10.18632/oncotarget.3817

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Masaki Shiota1, Akira Yokomizo1, Ario Takeuchi1, Kenjiro Imada1, Keijiro Kiyoshima1, Junichi Inokuchi1, Katsunori Tatsugami1, Saiji Ohga2, Katsumasa Nakamura2, Hiroshi Honda2 and Seiji Naito1

1 Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

2 Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

Correspondence to:

Akira Yokomizo, email:

Keywords: androgen-deprivation therapy, bladder cancer, prostate cancer, radical prostatectomy, radiotherapy

Received: January 21, 2015 Accepted: March 03, 2015 Published: April 14, 2015


Radiotherapy for prostate cancer is associated with an increased incidence of secondary bladder cancer (BC). We investigated the incidence, clinicopathological characteristics, and prognosis of BC after radiotherapy, surgical therapy, and primary androgen-deprivation therapy (ADT) for prostate cancer. This study included 1,334 Japanese patients with prostate cancer treated with radiotherapy (n=631), surgical therapy (n=437), and primary ADT (n=266). During the median follow-up period of 51.2, 44.8, and 45.5 months, secondary BC occurred in 14 (2.2%), 5 (1.1%), and 0 (0%) of patients with prostate cancer treated with radiotherapy, surgical therapy, and primary ADT, respectively. The 10-year BC-free survival rate was 91.3% in the radiotherapy group, 97.4% in the surgical therapy group, and 100% in the primary ADT group. The rates of intravesical recurrence, progression to muscle-invasive BC, and BC-specific death might be higher in secondary BC after radiotherapy compared with after surgical therapy. There was a significant difference in the incidence of secondary BC among different therapeutic modalities for prostate cancer in Japanese men, indicating significantly lower comorbidity rates of secondary BC after primary ADT for prostate cancer compared with radiotherapy.

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