Research Papers: Gerotarget (Focus on Aging):

Prevalence and predictive factors of osteoporosis in systemic sclerosis patients: a case-control study

Mathilde Marot, Antoine Valéry, Eric Esteve, Guido Bens, Adelheid Müller, Stéphanie Rist, Hechmi Toumi _ and Eric Lespessailles

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Oncotarget. 2015; 6:14865-14873. https://doi.org/10.18632/oncotarget.3806

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Mathilde Marot1,5, Antoine Valéry2, Eric Esteve3, Guido Bens3, Adelheid Müller5, Stéphanie Rist5, Hechmi Toumi4,5 and Eric Lespessailles4,5

1 Service de Rhumatologie, Centre Hospitalier Universitaire de Tours, France

2 Service du D.I.M., Centre Hospitalier Régional d’Orléans, La Source, France

3 Service de Dermatologie, Centre Hospitalier Régional d’Orléans, Porte Madeleine

4 Univ. Orléans, Orleans, France

5 Service de Rhumatologie, Centre Hospitalier Régional d’Orléans, La Source, France

Correspondence to:

Hechmi Toumi, email:

Keywords: osteopenia, densitometry, trabecular bone, chronic inflammatory, rheumatic diseases

Received: February 18, 2015 Accepted: March 18, 2015 Published: April 12, 2015


Purpose: Investigate the prevalence of osteoporosis in patients with systemic sclerosis (SSc) and describe alterations of bone tissue with High-Resolution peripheral Quantitative Computed Tomography (HR-pQCT).

Methods: Thirty-three patients and 33 controls matched on age, body mass index (BMI) and menopause were included. Bone mineral density (BMD) was measured at the lumbar spine (LS), femoral neck (FN) and total hip (TH) by dual energy X-ray absorptiometry. Volumetric BMD (vBMD) and bone microarchitecture were measured by HR-pQCT at tibia and radius.

Results: In patients, BMI was significantly lower, the prevalence of osteoporosis was significantly higher and HR-pQCT analysis showed a significant alteration of the trabecular compartment with a decrease in trabecular vBMD on both sites than in controls. In multivariate analysis, a low lean body mass, presence of anticentromere antibodies and older age were identified as independent factors for decreased BMD at LS (r²=0.43), FN (r²=0.61) and TH (r²=0.73). History or current digital ulcers were also identified as an independent factor for microarchitecture alteration.

Conclusion: In patients an increased prevalence of osteoporosis was found and HR-pQCT showed impaired trabecular bone compartment. Also, low lean body mass, high age, digital ulcers and ACAs were identified as independent risk factors for bone damage.

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