Oncotarget

Research Papers:

Hepatocellular carcinoma cases with high levels of c-Raf-1 expression may benefit from postoperative adjuvant sorafenib after hepatic resection even with high risk of recurrence

Jianyong Lei _, Jinjing Zhong, Jincheng Hao, Zhengni Liu, Peng Zhang, Lixue Wu, Lunan Yan, Jinqiang Zhu, Yong Zeng, Bo Li, Tianfu Wen and Wentao Wang

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Oncotarget. 2016; 7:42598-42607. https://doi.org/10.18632/oncotarget.3799

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Abstract

Jianyong Lei1,2,5, Jinjing Zhong3, Jingcheng Hao2, Zhengni Liu2, Peng Zhang4, Lixue Wu3, Lunan Yan2, Jinqiang Zhu1, Yong Zeng2, Bo Li2, Tianfu Wen2 and Wentao Wang2

1 Thyroid and Parathyroid Surgery Center, West China Hospital of Sichuan University, Chengdu, China

2 Liver Surgery, West China Hospital of Sichuan University, Chengdu, China

3 Department of Pathology, West China Hospital of Sichuan University, Chengdu, China

4 Third General Surgery, The First Hospital of Handan, Handan, Hebei, China

5 State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, China

Correspondence to:

Wentao Wang, email:

Jinqiang Zhu, email:

Keywords: hepatocellular carcinoma, recurrence, sorafenib, risk factors, liver resection

Received: March 01, 2015 Accepted: March 20, 2015 Published: March 13, 2016

Abstract

Background and Aims: Liver resection combined with postoperative sorafenib to prevent recurrence remains a controversial approach for cases of hepatocellular carcinoma (HCC), especially cases with a high risk of recurrence. This study aimed to investigate the efficacy and safety of liver resection combined with sorafenib for HCC with a high risk of recurrence.

Results: Most of the cases of HCC were caused by hepatitis B virus (HBV) infection (23 cases, 92%). Most of these tumors (21 cases, 84%) were stage III according to the TNM staging system (12 cases with IIIa, 9 cases with IIIb). In the months after hepatic resection, 19 of the 25 cases (76%) were diagnosed with HCC recurrence or metastasis. Based on the tumor histological biomarker grading system, the group with higher expression levels of c-Raf-1 showed significantly longer overall survival than the group with lower expression of c-Raf-1 (P = 0.012). However, the long-term tumor-free survival advantage disappeared (P = 0.061). Univariate and multivariate analyses indicated that higher expression of c-Raf-1 was significantly associated with better overall survival (hazard ratio [HR]: 1.842; 95% confidence interval [CI]: 1.211–2.542; P = 0.031) and tumor-free survival (HR: 1.319; 95% CI: 1.017–1.543; P = 0.046) in HCC patients who underwent radical hepatic resection.

Patients and Methods: We retrospectively collected 25 HCC cases with a high risk of recurrence who underwent radical liver resection and who took sorafenib postoperatively from Jan 2010 to Dec 2012. Factors that might contribute to tumor recurrence and treatment failure such as clinical factors, tumor features, and molecular biomarkers were included in our analysis.

Conclusions: HCC patients with a high risk of post-hepatic resection recurrence may benefit from postoperative sorafenib administered as an adjuvant therapy, especially in cases with high levels of c-Raf-1 expression on histological examination.


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