miR-221/222 induces pancreatic cancer progression through the regulation of matrix metalloproteinases
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Qinhong Xu1,*, Pei Li1,2,*, Xin Chen1, Liang Zong1, Zhengdong Jiang1, Ligang Nan1, Jianjun Lei1, Wanxing Duan1, Dong Zhang1, Xuqi Li3, Huanchen Sha1, Zheng Wu1 Qingyong Ma1 and Zheng Wang1
1 Department of Hepatobiliary Surgery, First Affiliated Hospital Medical College of Xi’an Jiaotong University, Xi’an, Shaanxi, China
2 Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shaanxi, China
3 Department of General Surgery, First Affiliated Hospital Medical College of Xi’an Jiaotong University, Xi’an, Shaanxi, China
* These authors have contributed equally to this work
Zheng Wang, email:
Keywords: miR-221/222, pancreatic cancer, matrix metalloproteinases
Received: December 20, 2014 Accepted: March 03, 2015 Published: March 29, 2015
MicroRNAs are involved in the initiation and progression of pancreatic cancer. In this study, we showed that miR-221/222 is overexpressed in pancreatic cancer. MiR-221/222 overexpression significantly promoted pancreatic cancer cell proliferation and invasion while inhibiting apoptosis. The expression of the matrix metalloproteinases (MMPs) MMP-2 and MMP-9 was increased in miR-221/222 mimic-transfected pancreatic cancer cells. Validation experiments identified TIMP-2 as a direct target of miR-221/222. These data indicate that overexpressed miR-221/222 may play an oncogenic role in pancreatic cancer by inducing the expression of MMP-2 and MMP-9, thus leading to cancer cell invasion.
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