Ubiquitin E3 ligase MARCH7 promotes ovarian tumor growth
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Jianguo Hu1, Ying Meng1, Tinghe Yu1, Lina Hu1, Ming Mao1
1 Department of Obstetrics and Gynecology, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China
Lina Hu, email:
Keywords: ovarian cancer, MARCH7, NF-Kb, Wnt, β-catenin
Received: October 21, 2014 Accepted: February 28, 2015 Published: March 26, 2015
Ubiquitin E3 ligase MARCH7 is involved in T cell proliferation and neuronal development. We found that expression of MARCH7 was higher in ovarian cancer tissues than normal ovarian tissues. Silencing MARCH7 decreased cell proliferation, migration, and invasion. Ectopic expression of MARCH7 increased cell proliferation, migration and invasion. Silencing MARCH7 prevented ovarian cancer growth in mice. Silencing MARCH7 inhibited NFkB and Wnt/β-catenin pathway. In agreement, ectopically expressed MARCH7 activated NFkB and Wnt/β-catenin pathways. Finally, MARCH7 was regulated by miR-101. Thus, MARCH7 is oncogenic and a potential target (oncotarget) for ovarian cancer therapy.
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