MicroRNAs in apoptosis, autophagy and necroptosis

Zhenyi Su, Zuozhang Yang _, Yongqing Xu, Yongbin Chen and Qiang Yu

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Oncotarget. 2015; 6:8474-8490. https://doi.org/10.18632/oncotarget.3523

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Zhenyi Su1,2,*, Zuozhang Yang3,4,*, Yongqing Xu4,*, Yongbin Chen5,*, Qiang Yu6,*

1Department of Biochemistry and Molecular Biology, Medical School, Southeast University, Nanjing, Jiangsu 210009, China

2Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA

3Bone and Soft Tissue Tumors Research Center of Yunnan Province, Department of Orthopaedics, the Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming, Yunnan 650118, China

4Department of Orthopaedics, Kunming General Hospital of Chengdu Military Command, Kunming, Yunnan 650118, China

5Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China

6Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

*These authors have contributed equally to this work

Correspondence to:

Zuozhang Yang, e-mail: [email protected]

Keywords: microRNA, apoptosis, autophagy, necroptosis, cancer progression

Received: February 02, 2015     Accepted: March 10, 2015     Published: April 02, 2015


MicroRNAs (miRNAs) are endogenous 22 nt non-coding RNAs that target mRNAs for cleavage or translational repression. Numerous miRNAs regulate programmed cell death including apoptosis, autophagy and necroptosis. We summarize how miRNAs regulate apoptotic, autophagic and necroptotic pathways and cancer progression. We also discuss how miRNAs link different types of cell death.

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