The multiple cellular functions of the oncoprotein Golgi phosphoprotein 3
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Stefano Sechi1,*, Anna Frappaolo1,*, Giorgio Belloni2, Gianni Colotti3, Maria Grazia Giansanti1
1Istituto di Biologia e Patologia Molecolari del CNR, Dipartimento di Biologia e Biotecnologie, Sapienza Università di Roma, 00185 Roma, Italy
2Dipartimento di Biologia e Biotecnologie, Sapienza Università di Roma, 00185 Roma, Italy
3Istituto di Biologia e Patologia Molecolari del CNR, Dipartimento di Scienze Biochimiche, Sapienza Università di Roma, 00185 Roma, Italy
* These authors have contributed equally to this work
Maria Grazia Giansanti, e-mail: [email protected]
Keywords: GOLPH3, cancer, Golgi
Received: November 06, 2014 Accepted: January 07, 2015 Published: January 23, 2015
The highly conserved Golgi phosphoprotein 3 (GOLPH3) protein, a component of Trans-Golgi Network (TGN), has been defined as a “first-in-class Golgi oncoprotein” and characterized as a Phosphatidylinositol 4-phosphate [PI(4)P] effector at the Golgi. GOLPH3 is commonly amplified in several solid tumors. Furthermore this protein has been associated with poor prognosis in many cancers. Highly conserved from yeast to humans, GOLPH3 provides an essential function in vesicle trafficking and Golgi structure. Recent data have also implicated this oncoprotein in regulation of cytokinesis, modulation of mitochondrial mass and cellular response to DNA damage. A minute dissection of the molecular pathways that require GOLPH3 protein will be helpful to develop new therapeutic cancer strategies.
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