Determination of genetic predisposition to early breast cancer in women of Kazakh ethnicity
Metrics: PDF 191 views | Full Text 1540 views | ?
Gulnur Zhunussova1,3, Nazgul Omarbayeva2,4, Dilyara Kaidarova2,4, Saltanat Abdikerim1,3, Natalya Mit1, Ilya Kisselev1, Kanagat Yergali1, Aigul Zhunussova1, Tatyana Goncharova2, Aliya Abdrakhmanova2,4 and Leyla Djansugurova1,3
1 Laboratory of Molecular Genetics, Institute of Genetics and Physiology, Almaty 050060, Kazakhstan
2 Kazakh Institute of Oncology and Radiology, Almaty 050060, Kazakhstan
3 Al-Farabi Kazakh National University, Almaty 050060, Kazakhstan
4 Asfendiyarov Kazakh National Medical University, Almaty 050060, Kazakhstan
|Gulnur Zhunussova,||email:||[email protected]|
|Nazgul Omarbayeva,||email:||[email protected]|
Keywords: early-onset breast cancer; triple negative breast cancer; next-generation sequencing; pathogenic variant; Kazakh population
Received: May 06, 2023 Accepted: September 21, 2023 Published: October 04, 2023
Breast cancer (BC) is the most common type of cancer among women in Kazakhstan. To date, little data are available on the spectrum of genetic variation in Kazakh women with BC. We aimed to identify population-specific genetic markers associated with the risk of developing early-onset BC and test their association with clinical and prognostic factors. The study included 224 Kazakh women diagnosed with BC (≤40 age). Entire coding regions (>1700 exons) and the flanking noncoding regions of 94 cancer-associated genes were sequenced from blood DNA using MiSeq platform. We identified 38 unique pathogenic variants (PVs) in 13 different cancer-predisposing genes among 57 patients (25.4%), of which 6 variants were novel. In total, 12 of the 38 distinct PVs were detected recurrently, including BRCA1 c.5266dup, c.5278-2del, and c.2T>C, and BRCA2 c.9409dup and c.9253del that may be founder in this population. BRCA1 carriers were significantly more likely to develop triple-negative BC (OR = 6.61, 95% CI 2.44–17.91, p = 0.0002) and have family history of BC (OR = 3.17, 95% CI 1.14–8.76, p = 0.03) compared to non-carriers. This study allowed the identification of PVs specific to early-onset BC, which may be used as a foundation to develop regional expertise and diagnostic tools for early detection of BC in young Kazakh women.
All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.