Oncotarget

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This article has been corrected. Correction in: Oncotarget. 2023; 14:890-892.

Utilizing metformin to prevent metabolic syndrome due to androgen deprivation therapy (ADT): a randomized phase II study of metformin in non-diabetic men initiating ADT for advanced prostate cancer

Devalingam Mahalingam _, Salih Hanni, Anthony V. Serritella, Christos Fountzilas, Joel Michalek, Brian Hernandez, John Sarantopoulos, Paromitta Datta, Ofelia Romero, Sureshkumar Mulampurath Achutan Pillai, John Kuhn, Michael Pollak and Ian M. Thompson

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Oncotarget. 2023; 14:622-636. https://doi.org/10.18632/oncotarget.28458

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Abstract

Devalingam Mahalingam1,2, Salih Hanni1, Anthony V. Serritella2, Christos Fountzilas1,3, Joel Michalek1, Brian Hernandez1, John Sarantopoulos4, Paromitta Datta5, Ofelia Romero1, Sureshkumar Mulampurath Achutan Pillai1, John Kuhn1, Michael Pollak6 and Ian M. Thompson1,7

1 Division of Hematology and Oncology, University of Texas Health Science Center, San Antonio, TX 77030, USA

2 Robert H Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA

3 Roswell Park Cancer Institute, Buffalo, NY 14263, USA

4 Institute for Drug Development, Mays Cancer Center at University of Texas Health, San Antonio, TX 78229, USA

5 Audie Murphy VA Hospital, San Antonio, TX 78229, USA

6 Division of Experimental Medicine, Lady Davis Institute of Medical Research, Jewish General Hospital, McGill University, Montreal, Canada

7 Christus Health, San Antonio, TX 78229, USA

Correspondence to:

Devalingam Mahalingam, email: [email protected]

Keywords: prostate cancer; metformin; metastatic; androgen deprivation therapy; clinical trial

Received: March 31, 2023     Accepted: June 01, 2023     Published: June 19, 2023

Copyright: © 2023 Mahalingam et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

ABSTRACT

Background: Androgen deprivation therapy (ADT) can lead to metabolic syndrome (MS) and is implicated in ADT-resistance. Metformin showed antineoplastic activity through mTOR inhibition secondary AMPK-activation.

Materials and Methods: To investigate whether metformin mitigated ADT-related MS, we conducted a randomized double-blind phase II trial of metformin 500 mg TID or placebo in non-diabetic patients with biochemically-relapsed or advanced PC due for ADT. Fasting serum glucose, insulin, PSA, metformin, weight and waist circumference (WC) were measured at baseline, week 12 and 28. The primary endpoint was a group of MS metrics. Secondary endpoints include PSA response, safety, serum metformin concentrations and analysis of downstream an mTOR target, phospho-S6-kinase.

Results: 36 men were randomized to either metformin or placebo. Mean age was 68.4. Mean weight, WC and insulin levels increased in both arms. At week 12 and 28, no statistical differences in weight, WC or insulin were observed in either arm. No significant difference in percentage of patients with PSA <0.2 at week 28 between metformin (45.5%) vs. placebo (46.7%). Analysis in the metformin-arm showed variable down-regulation of phospho-S6 kinase.

Conclusions: In our small study, metformin added to ADT did not show a reduced risk of ADT-related MS or differences in PSA response.


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