Myeloid-derived suppressor cells: Cancer, autoimmune diseases, and more
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Masahiko Shibata1,2,3,4, Kotaro Nanno2,5, Daigo Yoshimori2,5, Takahiro Nakajima2,3, Makoto Takada4,6, Takashi Yazawa2,3,4, Kousaku Mimura3, Norio Inoue2,3,4, Takafumi Watanabe7, Kazunoshin Tachibana8, Satoshi Muto9, Tomoyuki Momma3,4, Yoshiyuki Suzuki1,4,10, Koji Kono1,3,4, Shungo Endo11 and Seiichi Takenoshita12
1 Department of Comprehensive Cancer Treatment and Research at Aizu, Fukushima Medical University, Fukushima, Japan
2 Department of Surgery, Cancer Treatment Center, Aizu Chuo Hospital, Fukushima, Japan
3 Department of Gastrointestinal Tract Surgery, Fukushima Medical University, Fukushima, Japan
4 Aizu Oncology Consortium, Fukushima, Japan
5 Department of Surgery, Nippon Medical School, Tokyo, Japan
6 Department of Surgery, Bange Kousei General Hospital, Fukushima, Japan
7 Department of Obstetrics and Gynecology, Fukushima Medical University, Fukushima, Japan
8 Department of Breast Surgery, Fukushima Medical University, Fukushima, Japan
9 Department of Chest Surgery, Fukushima Medical University, Fukushima, Japan
10 Department of Radiation Oncology, Fukushima Medical University, Fukushima, Japan
11 Department of Colorectoanal Surgery, Aizu Medical Center, Fukushima Medical University, Fukushima, Japan
12 Fukushima Medical University, Fukushima, Japan
Keywords: MDSC; immunosuppression; Treg; TAM; cancer
Received: September 02, 2022 Accepted: October 20, 2022 Published: November 17, 2022
Although cancer immunotherapy using immune checkpoint inhibitors (ICIs) has been recognized as one of the major treatment modalities for malignant diseases, the clinical outcome is not uniform in all cancer patients. Myeloid-derived suppressor cells (MDSCs) represent a heterogeneous population of immature myeloid cells that possess various strong immunosuppressive activities involving multiple immunocompetent cells that are significantly accumulated in patients who did not respond well to cancer immunotherapies. We reviewed the perspective of MDSCs with emerging evidence in this review.
Many studies on MDSCs were performed in malignant diseases. Substantial studies on the participation of MDSCs on non-malignant diseases such as chronic infection and autoimmune diseases, and physiological roles in obesity, aging, pregnancy and neonates have yet to be reported. With the growing understanding of the roles of MDSCs, variable therapeutic strategies and agents targeting MDSCs are being investigated, some of which have been used in clinical trials. More studies are required in order to develop more effective strategies against MDSCs.
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