Research Perspectives:

FSP1, a novel KEAP1/NRF2 target gene regulating ferroptosis and radioresistance in lung cancers

Nsengiyumva Emmanuel, Hongen Li, Jing Chen and Yilei Zhang _

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Oncotarget. 2022; 13:1136-1139. https://doi.org/10.18632/oncotarget.28301

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Nsengiyumva Emmanuel1,*, Hongen Li2,*, Jing Chen3 and Yilei Zhang1,4

1 The Institute of Molecular and Translational Medicine, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi’an Jiaotong University, Xi’an 710049, China

2 Department of Thoracic Surgery, Ruyang People’s Hospital, Luoyang 471200, China

3 Shaanxi Stem Cell Application Engineering Research Center, Shaanxi Jiuzhou Biomedical Science and Technology Group, Xi’an 710065, China

4 Department of Thoracic Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China

* These authors contributed equally to this work

Correspondence to:

Yilei Zhang, email: zhangyilei@xjtu.edu.cn

Keywords: KEAP1/NRF2; lung cancer; ferroptosis; radioresistance; therapy

Received: September 05, 2022     Accepted: October 12, 2022     Published: October 19, 2022

Copyright: © 2022 Emmanuel et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


In the study of "A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers" which was published earlier in Nature Communications, the authors have identified a novel KEAP1/NRF2 target gene, FSP1, and demonstrated that FSP1 plays an essential role in NRF2-mediated ferroptosis resistance and radioresistance in KEAP1-deficient lung cancer cells. Currently, many NRF2 target genes have been found to participate in the regulation of ferroptosis, and exactly which one plays a dominant role seems unclear. This study proposes that FSP1 is the key effector in NRF2-mediated ferroptosis resistance and radioresistance in KEAP-deficient lung cancer cells, as we discussed in the manuscript.

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