FSP1, a novel KEAP1/NRF2 target gene regulating ferroptosis and radioresistance in lung cancers
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Nsengiyumva Emmanuel1,*, Hongen Li2,*, Jing Chen3 and Yilei Zhang1,4
1 The Institute of Molecular and Translational Medicine, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi’an Jiaotong University, Xi’an 710049, China
2 Department of Thoracic Surgery, Ruyang People’s Hospital, Luoyang 471200, China
3 Shaanxi Stem Cell Application Engineering Research Center, Shaanxi Jiuzhou Biomedical Science and Technology Group, Xi’an 710065, China
4 Department of Thoracic Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China
* These authors contributed equally to this work
Keywords: KEAP1/NRF2; lung cancer; ferroptosis; radioresistance; therapy
Received: September 05, 2022 Accepted: October 12, 2022 Published: October 19, 2022
In the study of "A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers" which was published earlier in Nature Communications, the authors have identified a novel KEAP1/NRF2 target gene, FSP1, and demonstrated that FSP1 plays an essential role in NRF2-mediated ferroptosis resistance and radioresistance in KEAP1-deficient lung cancer cells. Currently, many NRF2 target genes have been found to participate in the regulation of ferroptosis, and exactly which one plays a dominant role seems unclear. This study proposes that FSP1 is the key effector in NRF2-mediated ferroptosis resistance and radioresistance in KEAP-deficient lung cancer cells, as we discussed in the manuscript.
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