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Emerging approaches of wound healing in experimental models of high-grade oral mucositis induced by anticancer therapy

Ana Chor, Maria Adriana Skeff, Christina Takiya, Raquel Gonçalves, Marcos Dias, Marcos Farina, Leonardo R. Andrade and Valeria de Mello Coelho _

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Oncotarget. 2021. [Epub ahead of print] https://doi.org/10.18632/oncotarget.28091

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Abstract

Ana Chor1, Maria Adriana Skeff1, Christina Takiya2, Raquel Gonçalves1, Marcos Dias3, Marcos Farina1, Leonardo R. Andrade1 and Valeria de Mello Coelho4

1 Laboratory of Biomineralization, Institute of Biomedical Sciences, Health Sciences Center, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, Brazil

2 Laboratory of Immunopathology, Institute of Biophysics Carlos Chagas Filho, Health Sciences Center, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, Brazil

3 Laboratory of Catalysis for Polymerization, Recycling and Biodegradable Polymers (LCPRB), Institute of Macromolecules Professor Eloisa Mano (IMA), Technological Center, Federal University of Rio de Janeiro, Rio de Janeiro 21941-598, Brazil

4 Laboratory of Immunophysiology, Institute of Biomedical Sciences, Health Sciences Center, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, Brazil

Correspondence to:

Valeria De Mello-Coelho, email: coelhova@histo.ufrj.br

Keywords: oral mucositis; inflammation; regeneration; polymers; tissue engineering

Received: May 03, 2021     Accepted: September 24, 2021     Published: PUBLISHED_DATE

Copyright: © 2021 Chor et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

ABSTRACT

Clinical guidelines for oral mucositis (OM) still consist in palliative care. Herein, we summarize cellular and molecular mechanisms of OM ulceration in response to chemical therapies in animal models. We discuss evidenced anti-inflammatory and anti-oxidant drugs which have not been ever used for OM, such as synthetic peptides as well as cell therapy with mesenchymal stem cells; amniotic membranes, mucoadhesive polymers loaded with anti-inflammatory agents and natural or synthetic electrospun. These approaches have been promising to allow the production of drug-loaded membranes, scaffolds for cells encapsulation or guided tissue regeneration.


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