Research Papers:

Effect of hypertension and medication use regularity on postoperative delirium after maxillofacial tumors radical surgery

Shuyi Kong, Jing Wang, Hui Xu _ and Kaiqiang Wang _

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Oncotarget. 2021; 12:1811-1820. https://doi.org/10.18632/oncotarget.28048

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Shuyi Kong1, Jing Wang3, Hui Xu2 and Kaiqiang Wang1

1 Department of Pain Management, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China

2 Department of Anesthesiology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China

3 Department of Emergency, The Second Affiliated Hospital of Shandong First Medical University, Shandong 271000, China

Correspondence to:

Hui Xu, email: [email protected]
Kaiqiang Wang, email: [email protected]

Keywords: the elderly; oral tumor surgery; hypertension; postoperative delirium

Received: June 15, 2021     Accepted: July 28, 2021     Published: August 31, 2021

Copyright: © 2021 Kong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


The incidence of postoperative delirium (POD) after maxillofacial tumors radical surgery is relatively high. There are a number of evidences showing the relationship between hypertension and decreased cerebral blood flow, as well as the relationship between cerebral ischemia and postoperative cognitive impairment. However, the impact of hypertension in the process of POD and related mechanisms remain unclear.

This study included 98 elderly patients who underwent maxillofacial tumors radical surgery in our hospital, from June 2020 to December 2020. We collected the general condition of patients and related research factors before surgery, and also collected related intraoperative factors. After that, we would follow up the patients for POD evaluation.

The incidence of POD in the hypertension group was 41%, compared with 12% in the nonhypertension group (P < 0.05). The incidence of POD in the irregular medication group was 62%, compared with 26% in the regular medication group (P < 0.05). Both hypertension (OR = 2.45, 95% CI = 1.11–5.72) and irregular medication use (OR = 2.35, 95% CI = 0.87–5.69) were independent risk factors for POD after this type of surgery in elderly patients.

Hypertension and medication use regularity are closely related to POD. This may be related to the delayed postoperative response caused by intraoperative cerebral ischemia.

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