Oncotarget

Research Papers:

Quantitative difference of oral pathogen between individuals with gastric cancer and individuals without cancer

Gyselle Ribeiro de Carvalho Oliveira, Carla de Castro Sant’ Anna _, Letícia Martins Lamarão, Adriana Costa Guimarães, Carlos Machado da Rocha, Marcelo de Oliveira Bahia, Carolina Rosal de Souza, Danielle Queiroz Calcagno, Paulo Pimentel de Assumpção and Rommel Rodriguez Burbano

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Oncotarget. 2021; 12:1677-1686. https://doi.org/10.18632/oncotarget.28034

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Abstract

Gyselle Ribeiro de Carvalho Oliveira1, Carla de Castro Sant’ Anna2,3, Letícia Martins Lamarão4, Adriana Costa Guimarães5, Carlos Machado da Rocha5, Marcelo de Oliveira Bahia6, Carolina Rosal de Souza6, Danielle Queiroz Calcagno2, Paulo Pimentel de Assumpção2 and Rommel Rodriguez Burbano2,3,6

1 School of Dentistry, Federal University of Pará, Belém, Pará, Brazil

2 High Complexity Oncology Unit, Federal University of Pará, Rua dos Mundurucus, Hospital Universitário João de Barros Barreto, 2º piso da UNACOM, Belém, Pará, Brazil

3 Ophir Loyola Hospital, Av. Gov Magalhães Barata, Belem, Pará, Brazil

4 Foundation Center for Hemotherapy and Hematology, Travessa Padre Eutíquio, Belém, Pará, Brazil

5 Federal Institute of Pará, Belém, Pará, Brazil

6 Institute of Biological Sciences, Federal University of Pará, Belém, Pará, Brazil

Correspondence to:

Carla de Castro Sant’ Anna, email: santannacarla@yahoo.com.br

Keywords: periodontal disease; microbiome; gastric cancer; oral pathogens

Received: December 08, 2020     Accepted: July 13, 2021     Published: August 17, 2021

Copyright: © 2021 Oliveira et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

ABSTRACT

The loss of teeth and lack of oral hygiene have been associated with the risk of developing gastric cancer (GC) in several populations evidenced in epidemiological studies. In this study, we quantitatively compared the proportion of oral pathogens in individuals with gastric cancer and individuals without cancer in a referral hospital in the city of Belém, Brazil. This study evaluated 192 patients with GC and 192 patients without cancer. Periodontal clinical examination was performed, and all individuals were submitted to the collection of salivary and dental biofilms. When comparing the median periodontal indexes in the gastric and cancer-free groups, it was statistically significant (p < 0.001) in the gastric cancer group compared to the probing depth of the periodontal pocket. Levels of bacterial DNA were observed in saliva and dental plaque, with a statistically significant difference (p < 0.001) between individuals with cancer and without neoplasia in all the bacteria surveyed. Significant relationships (p < 0.001) between biological agents and GC have been found in bacterial species that cause high rates of periodontal pathology and caries. The results suggest a different quantitative association in the presence of oral pathogens between individuals without cancer and patients with GC. As noted, it cannot be said that the bacteria present in the oral cavity increase the risk of gastric cancer or are aggravating factors of the disease. However, it is worth mentioning that, as it is part of the digestive system, the lack of care for the oral cavity can negatively affect the treatment of patients with gastric cancer.


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