Research Perspectives:

The significance of ovarian fibrosis

David A. Landry, Het T. Vaishnav and Barbara C. Vanderhyden _

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Oncotarget. 2020; 11:4366-4370. https://doi.org/10.18632/oncotarget.27822

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David A. Landry1, Het T. Vaishnav1 and Barbara C. Vanderhyden1

1 Cancer Therapeutics Program, Ottawa Hospital Research Institute and Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Canada

Correspondence to:

Barbara C. Vanderhyden,email: [email protected]

Keywords: ovarian fibrosis; ovarian cancer; female reproduction; fertility; metformin

Received: October 30, 2020     Accepted: November 03, 2020     Published: November 24, 2020

Copyright: © 2020 Landry et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Ovarian aging is associated with significant changes in the structural organization of collagen, resulting in ovarian fibrosis. In many other tissues, fibrosis increases risks associated with tumorigenesis and metastasis. Thus, it is possible that ovarian fibrosis increases the risk of ovarian cancer by creating a microenvironment more permissive to tumor growth. In this research perspective, we review the impact of female reproduction on the development of ovarian fibrosis and the contributions of genetic and hormonal disruptions such as BRCA mutation, polycystic ovarian syndrome, and infertility to structural changes in the ovary and their relative risk of ovarian cancer. We also explore new fundamental questions in the field of ovarian fibrosis and possible prevention strategies such as metformin.

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