Case Reports:

This article has an addendum. Addendum in: Oncotarget. 2023; 14:542-542.

Laser speckle flowgraphy in juxtapapillary retinal capillary hemangioblastoma: a case report on natural course and therapeutic effect

Mizuho Mitamura, Satoru Kase _, Kiriko Hirooka and Susumu Ishida

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Oncotarget. 2020; 11:3800-3804. https://doi.org/10.18632/oncotarget.27771

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Mizuho Mitamura1,2, Satoru Kase1, Kiriko Hirooka1 and Susumu Ishida1

1 Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan

2 Department of Ophthalmology, Teine Keijinkai Hospital, Sapporo, Japan

Correspondence to:

Satoru Kase,email: [email protected]

Keywords: juxtapapillary retinal capillary hemangioblastoma; laser photocoagulation; laser speckle flowgraphy; fluorescein angiography; von Hippel-Lindau disease

Received: July 22, 2020     Accepted: September 29, 2020     Published: October 20, 2020

Copyright: © 2020 Mitamura et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Juxtapapillary retinal capillary hemangioblastoma (JRCH), a benign intraocular vascular tumor, is usually progressive and may lead to severe vision loss due to various complications. We herein present a case of JRCH observed with laser speckle flowgraphy (LSFG) before and after laser photocoagulation (LPC). A 21-year-old Japanese woman underwent LSFG evaluations. Right eye showed an orange-colored tumor consistent with JRCH on the papillomacular bundle, where LSFG showed a mild warm-color blood flow signal. Eight months after the first examination, JRCH in the right eye increased redness with vasodilatation, and the size enlarged, where LSFG showed a stronger warm-color blood flow signal. She underwent direct yellow laser ablation for the JRCH lesion. One week after LPC, JRCH became paler and LSFG eventually depicted a weakened blood flow signal at the same site. In conclusion, non-invasive and reproducible LSFG is a useful tool for assessing not only JRCH activity but also therapeutic effect.

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