Research Perspectives:

Novel insights into the synergistic interaction of Bortezomib and TRAIL: tBid provides the link

Simone Fulda _

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Oncotarget. 2011; 2:418-421. https://doi.org/10.18632/oncotarget.277

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Simone Fulda

1Institute for Experimental Cancer Research in Pediatrics, Goethe-University Frankfurt, Komturstr. 3a, 60528 Frankfurt, Germany

Keywords: cancer, apoptosis, chemotherapy, proteasome inhibitor, TRAIL

Received: April 19, 2011; Accepted: May 14, 2011; Published: May 16, 2011;


Simone Fulda, e-mail:


The proteasome inhibitor Bortezomib has been identified as a potent enhancer of TRAIL-induced apoptosis in several human cancers. However, the identification of the underlying molecular mechanisms of this synergistic cell death induction has been ongoing over the last years. A recent study identifies a new mechanism of action for the synergism of TRAIL and Bortezomib.

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