By downregulating TIAM1 expression, microRNA-329 suppresses gastric cancer invasion and growth

Zheng Li; Xin Yu; Yang Wang; Jianxiong Shen; William Ka Kei Wu; Jinqian Liang; Fan Feng

doi:10.18632/oncotarget.2755

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Research Papers:

By downregulating TIAM1 expression, microRNA-329 suppresses gastric cancer invasion and growth

Zheng Li _, Xin Yu, Yang Wang, Jianxiong Shen, William Ka Kei Wu, Jinqian Liang and Fan Feng

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Oncotarget. 2015; 6:17559-17569. https://doi.org/10.18632/oncotarget.2755

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Abstract

Zheng Li1, Xin Yu1, Yang Wang2, Jianxiong Shen1, William Ka Kei Wu3, Jinqian Liang1, Fan Feng1

1Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

2Department of Abdominal Surgery, Cancer Institute and Cancer Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China

3Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, China

Correspondence to:

Jianxiong Shen, e-mail: [email protected]

Keywords: Gastric cancer, MicroRNAs, miR-329, TIAM1

Received: November 09, 2014 Accepted: November 16, 2014 Published: February 11, 2015

ABSTRACT

Gastric cancer (GC) is one of the most common malignant tumors worldwide. Emerging evidence has shown that abnormal microRNAs (miRNAs) expression is involved in tumorigenesis. MiR-329 was previously reported to act as a tumor suppressor or oncogene in some types of cancer. However, its function in gastric cancer (GC) is unclear. Here, we found that miR-329 was down-regulated in GC compared with adjacent controls. Enforced expression of miR-329 inhibited proliferation, migration and invasion of gastric cancer cells in vitro. We identified T lymphoma invasion and metastasis 1 (TIAM1) gene as potential target of miR-329. MiR-329 levels inversely correlated with TIAM1 expression in GC. Importantly, TIAM1 rescued the miR-329-mediated inhibition of cell invasion and proliferation. Finally, reintroduction of miR-329 significantly inhibited tumor formation of GC in the xenograft mice. Our findings suggest that miR-329 is a tumor suppressor and potential therapeutic target of GC.

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Research Papers:

By downregulating TIAM1 expression, microRNA-329 suppresses gastric cancer invasion and growth

Abstract